Impact of di-(2-ethylhexyl) phthalate on the uterus of adult Wistar rats

被引：24

作者：

Somasundaram, D. B. ^{[1
]}

Manokaran, K. ^{[2
]}

Selvanesan, B. C. ^{[1
]}

Bhaskaran, R. S. ^{[1
]}

机构：

[1] Univ Madras, Inst Basic Med Sci, Dept Endocrinol, Madras, Tamil Nadu, India

[2] Manipal Univ, Sch Allied Hlth Sci, Manipal, Karnataka, India

来源：

HUMAN & EXPERIMENTAL TOXICOLOGY | 2017年 / 36卷 / 06期

关键词：

DEHP; estrogen receptors; progesterone receptors; PPAR; uterus; PROLIFERATION; METABOLISM; FERTILITY; TOXICITY; EXPOSURE; LIGANDS;

D O I：

10.1177/0960327116657601

中图分类号：

R99 [毒物学（毒理学）];

学科分类号：

100405 ;

摘要：

Di-(2-ethylhexyl) phthalate (DEHP) is the most common plasticizer used in polyvinyl chloride-based plastics. DEHP is not covalently bound to the plastics and is easily released to the environment, resulting in human exposure. In this study, the adult rats were exposed to DEHP and its effects on the uterus was evaluated. Healthy adult female rats were treated with DEHP orally (with dose level 0, 1, 10, and 100 mg/kg body weight/day) for 30 days. No significant changes in the body weight and wet uterine weight were observed. Ovarian hormones and their receptor levels in the uterus were increased. Histological studies exhibited the structural abnormalities such as decrease in diameter, thinning of the layers and disruption in the glandular epithelium.

引用

页码：565 / 572

页数：8

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