8th European Conference on Infections in Leukaemia: 2020 guidelines for the use of antibiotics in paediatric patients with cancer or post-haematopoietic cell transplantation

被引：91

作者：

Lehrnbecher, Thomas ^{[1
]}

Averbuch, Dina ^{[2
]}

Castagnola, Elio ^{[3
]}

Cesaro, Simone ^{[4
]}

Ammann, Roland A. ^{[5
]}

Garcia-Vidal, Carolina ^{[6
,7
]}

Kanerva, Jukka ^{[8
,9
]}

Lanternier, Fanny ^{[10
]}

Mesini, Alessio ^{[3
]}

Mikulska, Malgorzata ^{[11
,12
]}

Pana, Dorothea ^{[13
]}

Ritz, Nicole ^{[14
]}

Slavin, Monica ^{[15
,16
]}

Styczynski, Jan ^{[17
]}

Warris, Adilia ^{[18
]}

Groll, Andreas H. ^{[19
]}

机构：

[1] Goethe Univ Frankfurt, Hosp Children & Adolescents, Pediat Hematol & Oncol, D-60590 Frankfurt, Germany

[2] Hadassah Hebrew Univ Med Ctr, Dept Pediat, Jerusalem, Israel

[3] IRCCS Ist Giannina Gaslini, Infect Dis Unit, Dept Pediat, Genoa, Italy

[4] Azienda Osped Univ Integrata, Dept Mother & Child, Pediat Hematol Oncol, Verona, Italy

[5] Bern Univ Hosp, Dept Pediat, Inselspital, Pediat Hematol & Oncol, Bern, Switzerland

[6] Univ Barcelona, Hosp Clin Barcelona, Dept Infect Dis, Barcelona, Spain

[7] Univ Barcelona, IDIBAPS, Barcelona, Spain

[8] Univ Helsinki, New Childrens Hosp, Div Hematol Oncol & Stem Cell Transplantat, Helsinki, Finland

[9] Helsinki Univ Hosp, Helsinki, Finland

[10] Univ Paris, Necker Enfants Malad Hosp, AP HP, Infect Dis Unit, Paris, France

[11] Univ Genoa, Dept Hlth Sci, Div Infect Dis, Genoa, Italy

[12] IRCCS Osped Policlin San Martino, Genoa, Italy

[13] European Univ Cyprus, Dept Med, Nicosia, Cyprus

[14] Univ Basel, Pediat Infect Dis & Vaccinol, Childrens Hosp, Basel, Switzerland

[15] Peter MacCallum Canc Ctr, Dept Infect Dis, Melbourne, Vic, Australia

[16] Peter MacCallum Canc Ctr, Natl Cent Re Infect Canc, Melbourne, Vic, Australia

[17] Nicolaus Copernicus Univ Torun, Coll Med, Dept Pediat Hematol & Oncol, Bydgoszcz, Poland

[18] Univ Exeter, MRC Ctr Med Mycol, Exeter, Devon, England

[19] Univ Childrens Hosp Munster, Ctr Bone Marrow Transplantat, Dept Pediat Hematol & Oncol, Infect Dis Res Program, Munster, Germany

来源：

LANCET ONCOLOGY | 2021年 / 22卷 / 06期

关键词：

RISK FEBRILE NEUTROPENIA; BLOOD-STREAM INFECTIONS; LACTAMASE-PRODUCING ENTEROBACTERIACEAE; PLACEBO-CONTROLLED TRIAL; ONCOLOGY PATIENTS; CIPROFLOXACIN PROPHYLAXIS; ANTIBACTERIAL PROPHYLAXIS; INTRAVENOUS ANTIBIOTICS; OUTPATIENT MANAGEMENT; CHILDREN;

D O I：

10.1016/S1470-2045(20)30725-7

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Paediatric patients with cancer and those undergoing haematopoietic cell transplantation are at high risk of bacterial infections. The 8th European Conference on Infections in Leukaemia (ECIL-8) convened a Paediatric Group to review the literature and to formulate recommendations for the use of antibiotics according to the European Society of Clinical Microbiology and Infectious Diseases grading system. The evaluation of antibacterial prophylaxis included mortality, bloodstream infection, febrile neutropenia, emergence of resistance, and adverse effects as endpoints. Initial antibacterial therapy and antibiotic de-escalation or discontinuation focused on patients with a clinically stable condition and without previous infection or colonisation by resistant bacteria, and on patients with a clinically unstable condition or with previous infection or colonisation by resistant bacteria. The final considerations and recommendations of the ECIL-8 Paediatric Group on antibacterial prophylaxis, initial therapy, and de-escalation strategies are summarised in this Policy Review.

引用

页码：E270 / E280

页数：11

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