Viraemia and clinical disease in Dorset Poll sheep following vaccination with live attenuated bluetongue virus vaccines serotypes 16 and 4

被引：41

作者：

Veronesi, Eva ^{[1
]}

Darpel, Karin E. ^{[1
]}

Hamblin, Chris ^{[1
]}

Carpenter, Simon ^{[1
]}

Takamatsu, Haru-Hisa ^{[1
]}

Anthony, Simon J. ^{[1
]}

Elliott, Heather ^{[1
]}

Mertens, Peter P. C. ^{[1
]}

Mellor, Philip S. ^{[1
]}

机构：

[1] Inst Anim Hlth, Vector Borne Dis Programme, Woking GU24 ONF, Surrey, England

来源：

VACCINE | 2010年 / 28卷 / 05期

基金：

英国生物技术与生命科学研究理事会;

关键词：

Bluetongue; Modified live vaccines; Clinical disease and viraemia; CULICOIDES-VARIIPENNIS DIPTERA; INACTIVATED VACCINE; BRITISH SHEEP; INFECTION; CERATOPOGONIDAE; RESPONSES; STRAINS; VECTOR; CATTLE; EUROPE;

D O I：

10.1016/j.vaccine.2009.10.107

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The spread of bluetongue virus (BTV) is most successfully controlled by vaccination of susceptible ruminant populations. Currently two different types of BTV vaccines are used for this purpose; inactivated, mostly monovalent vaccine formulations and modified live virus vaccines (MLVs). Clinical signs and viraemia in Dorset Poll sheep vaccinated with BTV-4 and BTV-16 MLVs or inoculated with homogenates of midges (C sonorensis and C. nubeculosus) previously infected with BTV-4 MLV are presented. All sheep vaccinated with the two MLVs mounted an infectious viraemia lasting for a minimum of 9 up to 23 days post vaccination and developed a range of clinical signs associated with BTV infection. Peak viraemia titres recorded in individual sheep ranged from 3.5 to 6.83 log(10) TCID50/ml indicating a high potential for infection of vector insects and onward transmission. The implications of these results are discussed with reference to the current outbreaks of BTV occurring in northern Europe and in relation to the future development of vaccines for this virus. Crown Copyright (C) 2009 Published by Elsevier Ltd. All rights reserved.

引用

页码：1397 / 1403

页数：7

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