Class switch recombination:: A comparison between mouse and human

被引：72
作者：
Pan-Hammarstrom, Qiang [1 ]
Zhao, Yaofeng [1 ]
Hammarstrom, Lennart [1 ]
机构：
[1] Karolinska Univ Hosp Huddinge, Dept Lab Med, Div Clin Immunol, SE-14186 Stockholm, Sweden
来源：
ADVANCES IN IMMUNOLOGY, VOL 93 | 2007年 / 93卷
基金：
瑞典研究理事会;
关键词：
D O I：
10.1016/S0065-2776(06)93001-6
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Humans and mice separated more than 60 million years ago. Since then, evolution has led to a multitude of changes in their genomic sequences. The divergence of genes has resulted in differences both in the innate and, adaptive immune systems. In this chapter we focus on species difference with regard to immunoglobulin class switch recombination (CSR). We have compared the immunoglobulin constant region gene loci from human and mouse, with an emphasis on the switch regions, genii line transcription promoters, and 3' enhancers. We have also compared pathways/factors that are involved in CSR. Although there are remarkable similarities in the cellular machinery involved in CSR, there are also a number of unique features in each species.
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页码：1 / 61
页数：61
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