The synthesis of water-soluble CDM-AM copolymer by irradiation and its solubilization effect on hydrophobic drugs

被引：3
作者：
Li, Yong-Fu [1 ]
Tang, Hong-Tao [2 ]
Zhou, Si-Jing [3 ]
机构：
[1] Guizhou Acad Agr Sci, Inst Integragted Agr Dev, Guiyang 550006, Guizhou, Peoples R China
[2] China Natl Childrens Ctr, Natl Ctr Child Nutriment Qual Supervis & Testing, Beijing, Peoples R China
[3] Beijing Radiat Ctr, Inst Radiat Microbiol, Beijing, Peoples R China
来源：
DESIGNED MONOMERS AND POLYMERS | 2018年 / 21卷 / 01期
关键词：
Irradiation; Solubility; beta-cyclodextrin; Copolymer; Fungicidal activity; BETA-CYCLODEXTRIN; DERIVATIVES; CHEMISTRY; STABILITY;
D O I：
10.1080/15685551.2018.1480681
中图分类号：
O63 [高分子化学（高聚物）];
学科分类号：
070305 ; 080501 ; 081704 ;
摘要：
The beta-cyclodextrin-acrylamide (CDM-AM) copolymer was prepared from acrylamide and beta-CD maleate (CDM) using Co-60 gamma-ray irradiation method. The optimized preparation conditions for the CDM-AM copolymer are as follows: CDM:AM mass ratio of 1:1; irradiation dose of 4 kGy; and using 20 mL of DMF water solution. The yield rate of CDM-AM was 75% in grams using these synthetic conditions. The effects of the CDM-AM copolymer on the solubility and fungicidal activity of natamycin (NM) and carbendazim (MBC) were investigated. The stability constant of NM.CDM-AM and MBC.CDM-AM complexes at 303 K were of 13,446.06 M-1 and 2595.3 M-1, respectively. The complexes were characterized using phase solubility diagrams, NMR spectra and FT-IR spectra. The analysis of the biological activities of these two complexes indicated that they possessed enhancing fungicidal activities compared to NM and MBC alone.
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页码：105 / 115
页数：11
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