Synthesis and Characterization of Chitosan-Acrylic Acid Based Hydrogels and Investigation the Properties of Bilayered Design with Incorporated Alginate Beads

被引:6
|
作者
Erceg, Tamara [1 ]
Brakus, Gaja [2 ]
Stupar, Alena [3 ]
Cvetinov, Miroslav [4 ]
Hadnadev, Miroslav [3 ]
Ristic, Ivan [1 ]
机构
[1] Univ Novi Sad, Novi Sad 21000, Serbia
[2] High Sch Jovan Jovanovic Zmaj, Novi Sad 21000, Serbia
[3] Univ Novi Sad, Inst Food Technol Novi Sad, Novi Sad 21000, Serbia
[4] Univ Novi Sad, Acad Arts, Novi Sad 21000, Serbia
关键词
Chitosan hydrogels; Free-radical polymerization; Alginate beads; Bilayer design; Rheological properties; POLYMERS; BEHAVIOR;
D O I
10.1007/s10924-022-02473-7
中图分类号
X [环境科学、安全科学];
学科分类号
08 ; 0830 ;
摘要
The paper presents the synthesis of hydrogels via free-radical polymerization, based on Chitosan (CS) grafted with Acrylic acid (AA), using a two-step procedure. Free-radical polymerization has given strong hydrogels with compact structure, dominant elastic behavior, and long linear viscoelastic region. The results of rheological studies have shown that obtained hydrogels have significantly improved mechanical properties in comparison to chitosan hydrogels obtained by other sustainable methods. A step forward in the investigation of the potential application of chitosan hydrogels in wound dressing systems has been made by preparation of the bilayer design by embedding a layer of active compound-loaded alginate beads into the contact surface between two conjoined units of CS/AA hydrogels. Wild garlic (Allium ursinum L.) dried extract was used as an active compound because of its antimicrobial activity and green properties. This system has demonstrated pH-dependent release of extract and higher shear elastic modulus values than ordinary disc gels. A conducted study has given preliminary results for the possible application of bilayer chitosan-based hydrogels in wound dressing systems and represents the first step towards extrapolating the proposed design across other application fields.
引用
收藏
页码:3737 / 3760
页数:24
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