Hippocampal VEGF is necessary for antidepressant-like behaviors but not sufficient for antidepressant-like effects of ketamine in rats

被引：29

作者：

Choi, Miyeon ^{[1
]}

Lee, Seung Hoon ^{[3
]}

Chang, Ho Lee ^{[2
]}

Son, Hyeon ^{[1
,3
]}

机构：

[1] Hanyang Univ, Dept Biochem & Mol Biol, 17 Haengdang Dong, Seoul 133791, South Korea

[2] Hanyang Univ, Coll Med, Dept Pharmacol, 17 Haengdang Dong, Seoul 133791, South Korea

[3] Hanyang Univ, Grad Sch Biomed Sci & Engn, 17 Haengdang Dong, Seoul 133791, South Korea

来源：

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE | 2016年 / 1862卷 / 07期

基金：

新加坡国家研究基金会;

关键词：

Rat; Depression; Ketamine; Neurogenesis; VEGF; ELEMENT-BINDING PROTEIN; RESISTANT MAJOR DEPRESSION; GROWTH-FACTOR VEGF; DENTATE GYRUS; ADULT NEUROGENESIS; IN-VITRO; CAMP; EXPRESSION; DISORDER; STRESS;

D O I：

10.1016/j.bbadis.2016.04.001

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

We investigated the effects of ketamine on both the temporal and spatial profiles of neural precursor cells located in the hippocampus, and on antidepressant-like behaviors in rats. A single dose of ketamine resulted in a significant increase in the number of 5-bromo-2-deoxyuridine-positive (BrdU(+)) cells in the dentate gyrus (DG) of rats at 24 h, but not at 28 days, after treatment completion. Ketamine caused antidepressant-like behaviors in the forced swim test (FST) and novelty suppressed feeding test (NSFT). Viral-mediated hippocampal knockdown of vascular endothelial growth factor (VEGF) produced depressive-like behaviors in the FST and NSFT, which were partially recovered by ketamine to the level observed in the control group. The behavioral effects of VEGF knock down were accompanied by a decrease in hippocampal neurogenesis, which was also partially recovered by ketamine. Our results suggest that basal hippocampal VEGF expression is necessary for ketamine-induced antidepressant like behaviors in rats, but ketamine-induced VEGF expression only partially contributes to hippocampal neurogenesis and the antidepressant-like effects of ketamine. (C) 2016 Published by Elsevier B.V.

引用

页码：1247 / 1254

页数：8

共 38 条

[1] Safety and Efficacy of Repeated-Dose Intravenous Ketamine for Treatment-Resistant Depression [J].

aan het Rot, Marije ;

Collins, Katherine A. ;

Murrough, James W. ;

Perez, Andrew M. ;

Reich, David L. ;

Charney, Dennis S. ;

Mathew, Sanjay J. .

BIOLOGICAL PSYCHIATRY, 2010, 67 (02) :139-145

[2] Ketamine and Rapid-Acting Antidepressants: A Window into a New Neurobiology for Mood Disorder Therapeutics [J].

Abdallah, Chadi G. ;

Sanacora, Gerard ;

Duman, Ronald S. ;

Krystal, John H. .

ANNUAL REVIEW OF MEDICINE, VOL 66, 2015, 66 :509-523

[3] Glial Loss in the Prefrontal Cortex Is Sufficient to Induce Depressive-like Behaviors [J].

Banasr, Mounira ;

Duman, Ronald S. .

BIOLOGICAL PSYCHIATRY, 2008, 64 (10) :863-870

[4] Antidepressant effects of ketamine in depressed patients [J].

Berman, RM ;

Cappiello, A ;

Anand, A ;

Oren, DA ;

Heninger, GR ;

Charney, DS ;

Krystal, JH .

BIOLOGICAL PSYCHIATRY, 2000, 47 (04) :351-354

[5] VEGF links hippocampal activity with neurogenesis, learning and memory [J].

Cao, L ;

Jiao, XY ;

Zuzga, DS ;

Liu, YH ;

Fong, DM ;

Young, D ;

During, MJ .

NATURE GENETICS, 2004, 36 (08) :827-835

[6] ECS-induced mossy fiber sprouting and BDNF expression are attenuated by ketamine pretreatment [J].

Chen, ACH ;

Shin, KH ;

Duman, RS ;

Sanacora, G .

JOURNAL OF ECT, 2001, 17 (01) :27-32

[7] Overexpression of Human GATA-1 and GATA-2 Interferes with Spine Formation and Produces Depressive Behavior in Rats [J].

Choi, Miyeon ;

Wang, Sung Eun ;

Ko, Seung Yeon ;

Kang, Hyo Jung ;

Chae, Seung Yeun ;

Lee, Seung Hoon ;

Kim, Yong-Seok ;

Duman, Ronald S. ;

Son, Hyeon .

PLOS ONE, 2014, 9 (10)

[8] A neurotrophic model for stress-related mood disorders [J].

Duman, Ronald S. ;

Monteggia, Lisa M. .

BIOLOGICAL PSYCHIATRY, 2006, 59 (12) :1116-1127

[9] Regulation of adult neurogenesis by antidepressant treatment [J].

Duman, RS ;

Nakagawa, S ;

Malberg, J .

NEUROPSYCHOPHARMACOLOGY, 2001, 25 (06) :836-844

[10] Acute administration of ketamine induces antidepressant-like effects in the forced swimming test and increases BDNF levels in the rat hippocampus [J].

Garcia, Leda S. B. ;

Comim, Clarissa M. ;

Valvassori, Samira S. ;

Reus, Gislaine Z. ;

Barbosa, Luciana M. ;

Andreazza, Ana Cristina ;

Stertz, Laura ;

Fries, Gabriel R. ;

Gavioli, Elaine Cristina ;

Kapczinski, Flavio ;

Quevedo, Joao .

PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY, 2008, 32 (01) :140-144

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