Epidemiologic Study of Charcot-Marie-Tooth Disease: A Systematic Review

被引：189

作者：

Lima Santos Barreto, Lidiane Carine ^{[1
]}

Oliveira, Fernanda Santos ^{[1
]}

Nunes, Paula Santos ^{[1
]}

Pinheiro de Franca Costa, Iandra Maria ^{[1
]}

Garcez, Catarina Andrade ^{[1
]}

Goes, Gabriel Mattos ^{[1
]}

Aquino Neves, Eduardo Luis ^{[1
]}

Siqueira Quintans, Jullyana de Souza ^{[1
]}

de Souza Araujo, Adriano Antunes ^{[1
]}

机构：

[1] UFS, Nucleo Posgrad Med, Rua Claudio Batista S-N Bairro Sanatorio, BR-49060100 Aracaju, SE, Brazil

来源：

NEUROEPIDEMIOLOGY | 2016年 / 46卷 / 03期

关键词：

Charcot-Marie-Tooth disease; Epidemiology; Prevalence; Public health; HEREDITARY MOTOR; GENETIC EPIDEMIOLOGY; SENSORY NEUROPATHY; CLINICAL ASPECTS; POPULATION; DUPLICATION; FREQUENCY; 17P11.2;

D O I：

10.1159/000443706

中图分类号：

R1 [预防医学、卫生学];

学科分类号：

1004 ; 120402 ;

摘要：

Background: Charcot-Marie-Tooth disease (CMT) is the most common inherited neuropathy. CMT is classified into 2 main subgroups: CMT type 1 (CMT1; demyelinating form) and CMT type 2 (CMT2; axonal form). The objectives of this study were to systematically review and assess the quality of studies reporting the incidence and/or prevalence of CMT worldwide. Summary: A total of 802 studies were initially identified, with only 12 meeting the inclusion criteria. CMT prevalence was reported in 10 studies and ranged from 9.7/100,000 in Serbia to 82.3/100,000 in Norway. The frequency of the main subtypes varied from 37.6 to 84% for CMT1 and from 12 to 35.9% for CMT2; the country with the lowest prevalence of CMT1 was Norway, and the country with the highest prevalence of CMT1 was Iceland; on the other hand, CMT2 was least prevalent in the United Kingdom and most prevalent in Norway. Key Messages: This review reveals the gaps that still exist in the epidemiological knowledge of CMT around the world. Published studies are of varying quality and utilise different methodologies, thus precluding a robust conclusion. Additional research focusing on epidemiological features of CMT in different nations and different ethnic groups is needed. (C) 2016 S. Karger AG, Basel

引用

页码：157 / 165

页数：9

共 27 条

[1] Charcot-Marie-Tooth disease and related neuropathies: Mutation distribution and genotype-phenotype correlation [J].