Advances in the Diagnosis and Treatment of Pediatric Acute Lymphoblastic Leukemia

被引：141

作者：

Inaba, Hiroto ^{[1
,2
]}

Pui, Ching-Hon ^{[1
,2
]}

机构：

[1] St Jude Childrens Res Hosp, Dept Oncol, Memphis, TN 38105 USA

[2] Univ Tennessee, Hlth Sci Ctr, Dept Pediat, Memphis, TN 38163 USA

来源：

JOURNAL OF CLINICAL MEDICINE | 2021年 / 10卷 / 09期

基金：

美国国家卫生研究院;

关键词：

acute lymphoblastic leukemia; pediatric; advances; diagnosis; treatment; MINIMAL RESIDUAL DISEASE; RECEPTOR T-CELLS; HIGH-RISK; INTRACHROMOSOMAL AMPLIFICATION; INOTUZUMAB OZOGAMICIN; PROGNOSTIC IMPORTANCE; THERAPEUTIC TARGET; GENOMIC LANDSCAPE; FREE SURVIVAL; YOUNG-ADULTS;

D O I：

10.3390/jcm10091926

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The outcomes of pediatric acute lymphoblastic leukemia (ALL) have improved remarkably during the last five decades. Such improvements were made possible by the incorporation of new diagnostic technologies, the effective administration of conventional chemotherapeutic agents, and the provision of better supportive care. With the 5-year survival rates now exceeding 90% in high-income countries, the goal for the next decade is to improve survival further toward 100% and to minimize treatment-related adverse effects. Based on genome-wide analyses, especially RNA-sequencing analyses, ALL can be classified into more than 20 B-lineage subtypes and more than 10 T-lineage subtypes with prognostic and therapeutic implications. Response to treatment is another critical prognostic factor, and detailed analysis of minimal residual disease can detect levels as low as one ALL cell among 1 million total cells. Such detailed analysis can facilitate the rational use of molecular targeted therapy and immunotherapy, which have emerged as new treatment strategies that can replace or reduce the use of conventional chemotherapy.

引用

页数：24

共 153 条

[1] The genetic basis and cell of origin of mixed phenotype acute leukaemia [J].

Alexander, Thomas B. ;

Gu, Zhaohui ;

Iacobucci, Ilaria ;

Dickerson, Kirsten ;

Choi, John K. ;

Xu, Beisi ;

Payne-Turner, Debbie ;

Yoshihara, Hiroki ;

Loh, Mignon L. ;

Horan, John ;

Buldini, Barbara ;

Basso, Giuseppe ;

Elitzur, Sarah ;

de Haas, Valerie ;

Zwaan, C. Michel ;

Yeoh, Allen ;

Reinhardt, Dirk ;

Tomizawa, Daisuke ;

Kiyokawa, Nobutaka ;

Lammens, Tim ;

De Moerloose, Barbara ;

Catchpoole, Daniel ;

Hori, Hiroki ;

Moorman, Anthony ;

Moore, Andrew S. ;

Hrusak, Ondrej ;

Meshinchi, Soheil ;

Orgel, Etan ;

Devidas, Meenakshi ;

Borowitz, Michael ;

Wood, Brent ;

Heerema, Nyla A. ;

Carrol, Andrew ;

Yang, Yung-Li ;

Smith, Malcolm A. ;

Davidsen, Tanja M. ;

Hermida, Leandro C. ;

Gesuwan, Patee ;

Marra, Marco A. ;

Ma, Yussanne ;

Mungall, Andrew J. ;

Moore, Richard A. ;

Jones, Steven J. M. ;

Valentine, Marcus ;

Janke, Laura J. ;

Rubnitz, Jeffrey E. ;

Pui, Ching-Hon ;

Ding, Liang ;

Liu, Yu ;

Zhang, Jinghui .

NATURE, 2018, 562 (7727) :373-+

[2] Clonal origins of ETV6-RUNX1+ acute lymphoblastic leukemia: studies in monozygotic twins [J].

Alpar, D. ;

Wren, D. ;

Ermini, L. ;

Mansur, M. B. ;

van Delft, F. W. ;

Bateman, C. M. ;

Titley, I. ;

Kearney, L. ;

Szczepanski, T. ;

Gonzalez, D. ;

Ford, A. M. ;

Potter, N. E. ;

Greaves, M. .

LEUKEMIA, 2015, 29 (04) :839-846

[3] Clinical Outcome of Children With Newly Diagnosed Philadelphia Chromosome-Positive Acute Lymphoblastic Leukemia Treated Between 1995 and 2005 [J].

Arico, Maurizio ;

Schrappe, Martin ;

Hunger, Stephen P. ;

Carroll, William L. ;

Conter, Valentino ;

Galimberti, Stefania ;

Manabe, Atsushi ;

Saha, Vaskar ;

Baruchel, Andre ;

Vettenranta, Kim ;

Horibe, Keizo ;

Benoit, Yves ;

Pieters, Rob ;

Escherich, Gabriele ;

Silverman, Lewis B. ;

Pui, Ching-Hon ;

Valsecchi, Maria Grazia .

JOURNAL OF CLINICAL ONCOLOGY, 2010, 28 (31) :4755-4761

[4] Integrative genomic analyses reveal mechanisms of glucocorticoid resistance in acute lymphoblastic leukemia [J].

Autry, Robert J. ;

Paugh, Steven W. ;

Carter, Robert ;

Shi, Lei ;

Liu, Jingjing ;

Ferguson, Daniel C. ;

Lau, Calvin E. ;

Bonten, Erik J. ;

Yang, Wenjian ;

McCorkle, J. Robert ;

Beard, Jordan A. ;

Panetta, John C. ;

Diedrich, Jonathan D. ;

Crews, Kristine R. ;

Pei, Deqing ;

Coke, Christopher J. ;

Natarajan, Sivaraman ;

Khatamian, Alireza ;

Karol, Seth E. ;

Lopez-Lopez, Elixabet ;

Diouf, Barthelemy ;

Smith, Colton ;

Gocho, Yoshihiro ;

Hagiwara, Kohei ;

Roberts, Kathryn G. ;

Pounds, Stanley ;

Kornblau, Steven M. ;

Stock, Wendy ;

Paietta, Elisabeth M. ;

Litzow, Mark R. ;

Inaba, Hiroto ;

Mullighan, Charles G. ;

Jeha, Sima ;

Pui, Ching-Hon ;

Cheng, Cheng ;

Savic, Daniel ;

Yu, Jiyang ;

Gawad, Charles ;

Relling, Mary, V ;

Yang, Jun J. ;

Evans, William E. .

NATURE CANCER, 2020, 1 (03) :329-+

[5] Rapamycin stimulates apoptosis of childhood acute lymphoblastic leukemia cells [J].

Avellino, R ;

Romano, S ;

Parasole, R ;

Bisogni, R ;

Lamberti, A ;

Poggi, V ;

Venuta, S ;

Romano, MF .

BLOOD, 2005, 106 (04) :1400-1406

[6] ETV6-RUNX1-positive childhood acute lymphoblastic leukemia: improved outcome with contemporary therapy [J].

Bhojwani, D. ;

Pei, D. ;

Sandlund, J. T. ;

Jeha, S. ;

Ribeiro, R. C. ;

Rubnitz, J. E. ;

Raimondi, S. C. ;

Shurtleff, S. ;

Onciu, M. ;

Cheng, C. ;

Coustan-Smith, E. ;

Bowman, W. P. ;

Howard, S. C. ;

Metzger, M. L. ;

Inaba, H. ;

Leung, W. ;

Evans, W. E. ;

Campana, D. ;

Relling, M. V. ;

Pui, C-H .

LEUKEMIA, 2012, 26 (02) :265-270

[7] NUTM1-Rearranged Infant and Pediatric B Cell Precursor Acute Lymphoblastic Leukemia: A Good Prognostic Subtype Identified in a Collaborative International Study [J].

Boer, Judith M. ;

Valsecchi, Maria Grazia ;

Hormann, Femke M. ;

Antic, Zeljko ;

Zaliova, Marketa ;

Schwab, Claire ;

Cazzaniga, Giovanni ;

Arfeuille, Chloe ;

Cave, Helene ;

Attarbaschi, Andishe ;

Strehl, Sabine ;

Escherich, Gabriele ;

Imamura, Toshihiko ;

Ohki, Kentaro ;

Gruber, Tanja A. ;

Sutton, Rosemary ;

Pastorczak, Agata ;

Lammens, Tim ;

Lambert, Frederic ;

Li, Chi Kong ;

Pau, Enrique Carrillo de Santa ;

Hoffmann, Steve ;

Moricke, Anja .

BLOOD, 2020, 136

[8] Resistance to anti-CD19/CD3 BiTE in acute lymphoblastic leukemia may be mediated by disrupted CD19 membrane trafficking [J].

Braig, Friederike ;

Brandt, Anna ;

Goebeler, Mariele ;

Tony, Hans-Peter ;

Kurze, Anna-Katharina ;

Nollau, Peter ;

Bumm, Thomas ;

Boettcher, Sebastian ;

Bargou, Ralf C. ;

Binder, Mascha .

BLOOD, 2017, 129 (01) :100-104

[9] A phase 1 study of inotuzumab ozogamicin in pediatric relapsed/refractory acute lymphoblastic leukemia (ITCC-059 study) [J].

Brivio, Erica ;

Locatelli, Franco ;

Lopez-Yurda, Marta ;

Malone, Andrea ;

Diaz-de-Heredia, Cristina ;

Bielorai, Bella ;

Rossig, Claudia ;

van der Velden, Vincent H. J. ;

Ammerlaan, Anneke C. J. ;

Thano, Adriana ;

van der Sluis, Inge M. ;

den Boer, Monique L. ;

Chen, Ying ;

Sleight, Barbara ;

Brethon, Benoit ;

Nysom, Karsten ;

Sramkova, Lucie ;

Ora, Ingrid ;

Vinti, Luciana ;

Chen-Santel, Christiane ;

Zwaan, Christian Michel .

BLOOD, 2021, 137 (12) :1582-1590

[10] How I treat infant leukemia [J].

Brown, Patrick ;

Pieters, Rob ;

Biondi, Andrea .

BLOOD, 2019, 133 (03) :205-214

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