Analysis of Spot Urine Protein to Creatinine Ratio as an Indicator of 24 Hours Urinary Protein Excretion in Nephrotic Syndrome

Aim: To analyze spot urine protein versus creatinine ratio as a predictor of 24hr urinary protein excretion in nephrotic syndrome Method: This cross sectional study was conducted at Shahida Islam Medical College, Lodhran during 1st January 2018 to 30th September 2018. The data was collected from 150 patients of both genders. Early morning urine examples were gathered as spot urine and estimated for urinary protein, creatinine and protein to creatinine ratios. That day, 24-hour urines were gathered from 8 am to 8 am. Blood tests were drawn for serum creatinine Results: There were 90 males and 60 females with mean age 25.6 +/- 11.7 years. The mean value of serum creatinine was 85.8 +/- 19.6 (umol/L) and urine creatinine was 6.2 +/- 1.6 (mmol/L) in selected patients. The Pakistani children and grown-up patients who were discharging in excess of 150 mg urinary protein for every day; uncovered protein: creatinine record and ratio 141 and 0.18 individually in irregular urine tests. The concentration of protein in the urine is influenced by urine volume just as protein discharge rate. Conclusion: Urine protein versus urine creatinine ratios in random urine sample are best indicators of 24 hours urinary total protein excretion in patients with and without renal insufficiency.