Perioperative Targeted Therapy Or Immunotherapy In Non-Small-Cell Lung Cancer

被引：15

作者：

Sa, Huanlan ^{[1
]}

Song, Peng ^{[2
,3
]}

Ma, Kewei ^{[4
]}

Gao, Yong ^{[1
]}

Zhang, Li ^{[2
,3
]}

Wang, Deqiang ^{[1
]}

机构：

[1] Binzhou Med Univ, Affiliated Hosp, Dept Pain Management, Binzhou 256603, Peoples R China

[2] Chinese Acad Med Sci, Peking Union Med Coll Hosp, Dept Resp Med, Beijing 100010, Peoples R China

[3] Peking Union Med Coll, Beijing 100010, Peoples R China

[4] Jilin Univ, Hosp 1, Dept Oncol Canc, Canc Ctr, Changchun 130021, Jilin, Peoples R China

来源：

ONCOTARGETS AND THERAPY | 2019年 / 12卷

关键词：

non-small-cell lung cancer; targeted therapy; immunotherapy; EGFR MUTATIONS; OPEN-LABEL; PHASE-III; GEFITINIB; CHEMOTHERAPY; ERLOTINIB; 1ST-LINE; PLACEBO;

D O I：

10.2147/OTT.S222412

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Targeted therapy and immunotherapy have changed the treatment modes for advanced non-small cell lung cancer (NSCLC), moving from second-line to first-line treatment and significantly extending patients' survival. Surgery and chemoradiotherapy remain the main treatment options for patients with locally advanced lung cancer, but recurrence and metastasis still occur in some patients. The survival rates of conventional perioperative chemotherapy among NSCLC patients have increased by only 5%. Therefore, more studies have begun to explore targeted and immune neoadjuvant/adjuvant therapies in early-stage and locally advanced NSCLC, and the relevant clinical research data have shown good efficacy and safety profiles. This article summarizes several clinical studies of critical importance.

引用

页码：8151 / 8159

页数：9

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