Design and Characterization of a Dedicated Cone-Beam CT Scanner for Detection of Acute Intracranial Hemorrhage

被引：1

作者：

Xu, J. ^{[1
]}

Sisniega, A. ^{[1
]}

Zbijewski, W. ^{[1
]}

Dang, H. ^{[1
]}

Stayman, J. W. ^{[1
]}

Wang, X. ^{[2
]}

Foos, D. H. ^{[2
]}

Aygun, N. ^{[3
]}

Koliatsos, V. E. ^{[4
]}

Siewerdsen, J. H. ^{[1
,3
]}

机构：

[1] Johns Hopkins Univ, Dept Biomed Engn, Baltimore, MD 21218 USA

[2] Carestream Hlth Inc, Rochester, NY USA

[3] Johns Hopkins Univ, Dept Radiol, Baltimore, MD USA

[4] Johns Hopkins Univ, Dept Neurol, Baltimore, MD 21218 USA

来源：

MEDICAL IMAGING 2016: PHYSICS OF MEDICAL IMAGING | 2016年 / 9783卷

关键词：

Cone-Beam CT; intracranial hemorrhage; task based detectability; system design; OPTIMIZATION; PERFORMANCE;

D O I：

10.1117/12.2216544

中图分类号：

O43 [光学];

学科分类号：

070207 ; 0803 ;

摘要：

Purpose: Prompt and reliable detection of intracranial hemorrhage (ICH) has substantial clinical impact in diagnosis and treatment of stroke and traumatic brain injury. This paper describes the design, development, and preliminary performance characterization of a dedicated cone-beam CT (CBCT) head scanner prototype for imaging of acute ICH. Methods: A task-based image quality model was used to analyze the detectability index as a function of system configuration, and hardware design was guided by the results of this model-based optimization A robust artifact correction pipeline was developed using GPU-accelerated Monte Carlo (MC) scatter simulation, beam hardening corrections, detector veiling glare, and lag deconvolution. An iterative penalized weighted least-squares (PWLS) reconstruction framework with weights adjusted for artifact-corrected projections was developed. Various bowtie filters were investigated for potential dose and image quality benefits, with a MC-based tool providing estimates of spatial dose distribution. Results: The initial prototype will feature a source-detector distance of 1000 mm and source-axis distance of 550 mm, a 43x43 cm(2) flat panel detector, and a 15 rotating anode x-ray source with 15 kW power and 0.6 focal spot size. Artifact correction reduced image nonuniformity by similar to 250 HU, and PWLS reconstruction with modified weights improved the contrast to noise ratio by 20%. Inclusion of a bowtie filter can potentially reduce dose by 50% and improve CNR by 25%. Conclusions: A dedicated CBCT system capable of imaging millimeter-scale acute ICH was designed. Preliminary findings support feasibility of point-of-care applications in 1131 and stroke imaging, with clinical studies beginning on a prototype.

引用

页数：7

共 17 条

[1] Cone-Beam CT of Traumatic Brain Injury Using Statistical Reconstruction with a Post-Artifact-Correction Noise Model
Dang, H.
Stayman, J. W.
Sisniega, A.
Xu, J.
Zbijewski, W.
Yorkston, J.
Aygun, N.
Koliatsos, V.
Siewerdsen, J. H.
[J]. MEDICAL IMAGING 2015: PHYSICS OF MEDICAL IMAGING, 2015, 9412
[2] Dang H., 2015, PHYS MED BIOL
[3] METHOD FOR CORRECTING BONE INDUCED ARTIFACTS IN COMPUTED TOMOGRAPHY SCANNERS
JOSEPH, PM
SPITAL, RD
[J]. JOURNAL OF COMPUTER ASSISTED TOMOGRAPHY, 1978, 2 (01) : 100 - 108
[4] Epidemiology of Concussion and Mild Traumatic Brain Injury
Laker, Scott R.
[J]. PM&R, 2011, 3 (10) : S354 - S358
[5] Mozaffarian D, 2015, CIRCULATION, V131, pE29, DOI 10.1161/CIR.0000000000000152
[6] Removal and effects of scatter-glare in cone-beam CT with an amorphous-silicon flat-panel detector
Poludniowski, G.
Evans, P. M.
Kavanagh, A.
Webb, S.
[J]. PHYSICS IN MEDICINE AND BIOLOGY, 2011, 56 (06) : 1837 - 1851
[7] Task-based modeling and optimization of a cone-beam CT scanner for musculoskeletal imaging
Prakash, P.
Zbijewski, W.
Gang, G. J.
Ding, Y.
Stayman, J. W.
Yorkston, J.
Carrino, J. A.
Siewerdsen, J. H.
[J]. MEDICAL PHYSICS, 2011, 38 (10) : 5612 - 5629
[8] Comparison of model and human observer performance for detection and discrimination tasks using dual-energy x-ray images
Richard, Samuel
Siewerdsen, Jeffrey H.
[J]. MEDICAL PHYSICS, 2008, 35 (11) : 5043 - 5053
[9] Cascaded systems analysis of noise reduction algorithms in dual-energy imaging
Richard, Samuel
Siewerdsen, Jeffrey H.
[J]. MEDICAL PHYSICS, 2008, 35 (02) : 586 - 601
[10] SHARP PE, 1996, 54 ICRU

← 1 2 →