Recent progress in synthetic self-adjuvanting vaccine development

被引：10

作者：

Ariawan, Daryl ^{[1
]}

van Eersel, Janet ^{[1
]}

Martin, Adam D. ^{[1
]}

Ke, Yazi D. ^{[1
]}

Ittner, Lars M. ^{[1
]}

机构：

[1] Macquarie Univ, Fac Med & Hlth Sci, Dementia Res Ctr, Dept Biomed Sci, Sydney, NSW 2109, Australia

来源：

BIOMATERIALS SCIENCE | 2022年 / 10卷 / 15期

关键词：

PEPTIDE AMPHIPHILE MICELLES; MONOPHOSPHORYL-LIPID-A; T-CELL; DELIVERY-SYSTEM; THERMORESPONSIVE HYDROGELS; IMMUNOLOGICAL EVALUATION; LIPOPEPTIDE VACCINE; ASSEMBLING PEPTIDE; IMMUNE-RESPONSES; DENDRITIC CELL;

D O I：

10.1039/d2bm00061j

中图分类号：

TB3 [工程材料学]; R318.08 [生物材料学];

学科分类号：

0805 ; 080501 ; 080502 ;

摘要：

Vaccination is a proven way to protect individuals against many infectious diseases, as currently highlighted in the global COVID-19 pandemic. Peptides- or small molecule antigen-based vaccination offer advantages over the classical vaccine approaches. However, peptides or small molecules by themselves are generally not sufficiently immunogenic, and thus require an adjuvant to boost an immune response. Several conjugated systems have been developed in recent years to overcome this obstacle. This review summarises different moieties which, when conjugated to peptide antigens, facilitate a specific immune response. Different classes of self-adjuvant moieties are reviewed, including self-assembly peptides, lipids, glycolipids, and polymers.

引用

页码：4037 / 4057

页数：21

共 129 条

[1] Design of Fully Synthetic, Self-Adjuvanting Vaccine Incorporating the Tumor-Associated Carbohydrate Tn Antigen and Lipoamino Acid-Based Toll-like Receptor 2 Ligand [J].

Abdel-Aal, Abu-Baker M. ;

El-Naggar, Dina ;

Zaman, Mehfuz ;

Batzloff, Michael ;

Toth, Istvan .

JOURNAL OF MEDICINAL CHEMISTRY, 2012, 55 (15) :6968-6974

[2] Immunological Evaluation of Co-Assembling a Lipidated Peptide Antigen and Lipophilic Adjuvants: Self-Adjuvanting Anti-Breast-Cancer Vaccine Candidates [J].

Aiga, Taku ;

Manabe, Yoshiyuki ;

Ito, Keita ;

Chang, Tsung-Che ;

Kabayama, Kazuya ;

Ohshima, Shino ;

Kametani, Yoshie ;

Miura, Ayane ;

Furukawa, Hiroto ;

Inaba, Hiroshi ;

Matsuura, Kazunori ;

Fukase, Koichi .

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2020, 59 (40) :17705-17711

[3] NKT cell-dependent glycolipid-peptide vaccines with potent anti-tumour activity [J].

Anderson, Regan J. ;

Compton, Benjamin J. ;

Tang, Ching-wen ;

Authier-Hall, Astrid ;

Hayman, Colin M. ;

Swinerd, Gene W. ;

Kowalczyk, Renata ;

Harris, Paul ;

Brimble, Margaret A. ;

Larsen, David S. ;

Gasser, Olivier ;

Weinkove, Robert ;

Hermans, Ian F. ;

Painter, Gavin F. .

CHEMICAL SCIENCE, 2015, 6 (09) :5120-5127

[4]

Anderson RJ, 2014, NAT CHEM BIOL, V10, P943, DOI [10.1038/NCHEMBIO.1640, 10.1038/nchembio.1640]

[5] Mucosal Vaccination with a Self-Adjuvanted Lipopeptide Is Immunogenic and Protective against Mycobacterium tuberculosis [J].

Ashhurst, Anneliese S. ;

McDonald, David M. ;

Hanna, Cameron C. ;

Stanojevic, Vicki A. ;

Britton, Warwick J. ;

Payne, Richard J. .

JOURNAL OF MEDICINAL CHEMISTRY, 2019, 62 (17) :8080-8089

[6] Self-adjuvanting vaccine against group A streptococcus: Application of fibrillized peptide and immunostimulatory lipid as adjuvant [J].

Azmi, Fazren ;

Fuaad, Abdullah Al Hadi Ahmad ;

Giddam, Ashwini Kumar ;

Batzloff, Michael R. ;

Good, Michael F. ;

Skwarczynski, Mariusz ;

Toth, Istvan .

BIOORGANIC & MEDICINAL CHEMISTRY, 2014, 22 (22) :6401-6408

[7] Poly(hydrophobic amino acid)-Based Self-Adjuvanting Nanoparticles for Group A Streptococcus Vaccine Delivery [J].

Azuar, Armira ;

Li, Zhuoqing ;

Shibu, Mohini A. ;

Zhao, Lili ;

Luo, Yacheng ;

Shalash, Ahmed O. ;

Khalil, Zeinab G. ;

Capon, Robert J. ;

Hussein, Waleed M. ;

Toth, Istvan ;

Skwarczynski, Mariusz .

JOURNAL OF MEDICINAL CHEMISTRY, 2021, 64 (05) :2648-2658

[8] Cholic Acid-based Delivery System for Vaccine Candidates against Group A Streptococcus [J].

Azuar, Armira ;

Zhao, Lili ;

Hei, Tsui Tin ;

Nevagi, Reshma J. ;

Bartlett, Stacey ;

Hussein, Waleed M. ;

Ithali, Zeinab G. ;

Capon, Robert J. ;

Toth, Istvan ;

Skwarczynski, Mariusz .

ACS MEDICINAL CHEMISTRY LETTERS, 2019, 10 (09) :1253-+

[9]

Bandyopadhyay AS, 2015, FUTURE MICROBIOL, V10, P791, DOI [10.2217/FMB.15.19, 10.2217/fmb.15.19]

[10] Vaccine adjuvants: smart components to boost the immune system [J].

Bastola, Rakesh ;

Noh, Gyubin ;

Keum, Taekwang ;

Bashyal, Santosh ;

Seo, Jo-Eun ;

Choi, Jaewoong ;

Oh, Yeonsu ;

Cho, YoungSik ;

Lee, Sangkil .

ARCHIVES OF PHARMACAL RESEARCH, 2017, 40 (11) :1238-1248

← 1 2 3 4 5 6 7 8 9 10 →