Plasma Epstein-Barr virus DNA as a biomarker for nasopharyngeal carcinoma

被引：54
作者：
Chan, K. C. Allen [1 ,2 ,3 ]
机构：
[1] Chinese Univ Hong Kong, Li Ka Shing Inst Hlth Sci, Shatin, Hong Kong, Peoples R China
[2] Chinese Univ Hong Kong, Dept Chem Pathol, Prince Wales Hosp, Shatin, Hong Kong, Peoples R China
[3] Chinese Univ Hong Kong, State Key Lab Oncol South China, Prince Wales Hosp, Sir YK Pao Ctr Canc, Shatin, Hong Kong, Peoples R China
来源：
CHINESE JOURNAL OF CANCER | 2014年 / 33卷 / 12期
关键词：
Plasma Epstein-Barr virus EBV DNA; tumor markers; nasopharyngeal carcinoma; cancer screening; CIRCULATING EBV DNA; COPY NUMBER ABERRATIONS; VIRAL CAPSID ANTIGEN; CELL-FREE; QUANTITATIVE-ANALYSIS; CANCER-PATIENTS; CLEARANCE RATE; NUCLEIC-ACIDS; SERUM; QUANTIFICATION;
D O I：
10.5732/cjc.014.10192
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Nasopharyngeal carcinoma (NPC) is common in southern China and Southeast Asia. Epstein-Barr virus (EBV) infection is an important etiology for NPC, and EBV genome can be detected in almost all tumor tissues of NPC in this region. Plasma EBV DNA, when quantitatively analyzed using real-time polynnerase chain reaction (PCR), has been developed as a biomarker for NPC. In this review, the different clinical applications of plasma EBV DNA in the management of NPC, including screening, monitoring, and prognostication, are discussed. In addition, the biological issues of circulating EBV DNA, including the molecular nature and clearance kinetics, are also explored.
引用
收藏
页码：598 / 603
页数：6
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