Copper-Mediated Trifluoromethylation Using Phenyl Trifluoromethyl Sulfoxide

被引：70

作者：

Li, Xinjin ^{[1
,2
]}

Zhao, Jingwei ^{[2
]}

Zhang, Liang ^{[2
]}

Hu, Mingyou ^{[2
]}

Wang, Limin ^{[1
]}

Hu, Jinbo ^{[2
]}

机构：

[1] E China Univ Sci & Technol, Inst Fine Chem, Key Lab Adv Mat, Shanghai 200237, Peoples R China

[2] Chinese Acad Sci, Shanghai Inst Organ Chem, Key Lab Organofluorine Chem, Shanghai 200032, Peoples R China

来源：

ORGANIC LETTERS | 2015年 / 17卷 / 02期

基金：

中国国家自然科学基金;

关键词：

AROMATIC-COMPOUNDS; NUCLEOPHILIC TRIFLUOROMETHYLATION; OXIDATIVE TRIFLUOROMETHYLATION; CARBONYL-COMPOUNDS; DIRECT CUPRATION; FLUOROFORM; ARYL; PERFLUOROALKYLATION; FLUORINATION; REACTIVITY;

D O I：

10.1021/ol5034018

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A new method for the generation of trifluoromethylcopper ("CuCF3") species from readily available phenyl trifluoromethyl sulfoxide has been developed. The "CuCF3" reagent can be applied in efficient trifluoromethylations of aryl iodides and activated aryl bromides in the absence of additional ligands. Furthermore, the "CuCF3" species can also undergo oxidative cross-coupling with terminal alkynes and arylboronic acids.

引用

页码：298 / 301

页数：4

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