Workers exposed to low levels of benzene present in urban air: Assessment of peripheral blood count variations

被引：33

作者：

Casale, Teodorico ^{[1
]}

Sacco, Carmina ^{[1
]}

Ricci, Serafino ^{[2
]}

Loreti, Beatrice ^{[1
]}

Pacchiarotti, Alessandro ^{[1
]}

Cupelli, Vincenzo ^{[3
]}

Arcangeli, Giulio ^{[3
]}

Mucci, Nicola ^{[3
,4
]}

Antuono, Vittorio ^{[1
]}

De Marco, Federica ^{[1
]}

Tomei, Gianfranco ^{[5
]}

Tomei, Francesco ^{[6
]}

Rosati, Maria Valeria ^{[1
]}

机构：

[1] Univ Roma La Sapienza, Dept Anat Histol Med Legal & Orthoped, Unit Occupat Med, Viale Regina Elena 336, I-00161 Rome, Italy

[2] Univ Roma La Sapienza, Dept Anat Histol Legal Med & Orthopaed, Piazzale Aldo Moro 5, I-00185 Rome, Italy

[3] Univ Florence, Dept Clin & Expt Med, Hlth Serv Res Unit, Chair Occupat Med, 1-23 Largo Piero Palagi, Florence, Italy

[4] Univ Cattolica Sacro Cuore, Inst Occupat Med, 1 Largo Francesco Vito, I-00168 Rome, Italy

[5] Univ Roma La Sapienza, Dept Psychiat & Psychol Sci, Piazzale Aldo Moro 5, I-00185 Rome, Italy

[6] Sipro, Viale Regina Elena 336, I-00161 Rome, Italy

来源：

CHEMOSPHERE | 2016年 / 152卷

关键词：

Airborne benzene; Blood benzene; White blood cells; Lymphocytes; Neutrophils; Urban pollution; PARAMETERS; CADMIUM; POLICE; HEALTH; CELLS; ROME;

D O I：

10.1016/j.chemosphere.2016.01.096

中图分类号：

X [环境科学、安全科学];

学科分类号：

08 ; 0830 ;

摘要：

Background: Few studies in the literature have examined the effects of benzene on blood cells. Aim: The aim of this study was to evaluate the possible correlation between the blood benzene levels and the blood cell counts. Materials and methods: From a population of 2658 workers, we studied a group of 215 subjects. Each worker underwent blood sampling for the assessment of the blood benzene levels and the blood cell counts. The Mann-Whitney U test for two-mode variables and the Kruskal-Wallis test for more-than two-mode variables were performed on all subjects. We estimated the Pearson correlation index between the variables in the total sample and the subgroups divided according to sex, the smoking habit, and job. After the main confounding factors were evaluated, multiple linear regression was performed on both the total sample and the subgroups. Results: A significant inverse correlation was found among the blood benzene levels and the white blood cells, lymphocytes, and neutrophils in traffic policemen, motorcyclists, and other outdoor workers. We did not find any significant correlation with any other parameters of blood cell count. Discussion and conclusions: Our results, which must be considered preliminary, indicate that increased blood benzene levels in outdoor workers lead to decreased counts of white blood cells, neutrophils, and lymphocytes, because of possible immune effects. These are worth investigating in the future by specific immune tests. (C) 2016 Published by Elsevier Ltd.

引用

页码：392 / 398

页数：7

共 35 条

[1] Attenuation by glutathione of hsp72 gene expression induced by cadmium in cisplatin-resistant human ovarian cancer cells [J].