RADIATION-ASSOCIATED LIVER INJURY

被引：544
作者：
Pan, Charlie C. [1 ]
Kavanagh, Brian D. [2 ]
Dawson, Laura A. [3 ]
Li, X. Allen [4 ]
Das, Shiva K. [5 ]
Miften, Moyed [2 ]
Ten Haken, Randall K. [1 ]
机构：
[1] Univ Michigan, Sch Med, Dept Radiat Oncol, Ann Arbor, MI 48109 USA
[2] Univ Colorado, Dept Radiat Oncol, Aurora, CO USA
[3] Univ Toronto, Princess Margaret Hosp, Toronto, ON, Canada
[4] Med Coll Wisconsin, Dept Radiat Oncol, Milwaukee, WI 53226 USA
[5] Duke Univ, Med Ctr, Dept Radiat Oncol, Durham, NC USA
来源：
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS | 2010年 / 76卷 / 03期
关键词：
Liver; Normal tissue toxicity; Radiation-induced liver disease; 3-DIMENSIONAL CONFORMAL RADIOTHERAPY; UNRESECTABLE HEPATOCELLULAR-CARCINOMA; STEREOTACTIC BODY RADIOTHERAPY; COMPLICATION PROBABILITY MODEL; PHASE-I; NORMAL-TISSUE; HEPATIC TOXICITY; THERAPY; METASTASES; DISEASE;
D O I：
10.1016/j.ijrobp.2009.06.092
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
The liver is a critically :Important organ that has numerous functions including the production of bile, metabolism of ingested nutrients, elimination of many waste products, glycogen storage, and plasma protein synthesis. The liver is often incidentally irradiated during radiation therapy (RT) for tumors in the upper- abdomen, right lower lung, distal esophagus, or during whole abdomen or whole body RT. This article describes the endpoints, time-course, and dose-volume effect of radiation on the liver. (C) 2010 Elsevier Inc.
引用
收藏
页码：S94 / S100
页数：7
相关论文
共 41 条
[1]   Influence of prognostic groupings and treatment results in the management of unresectable hepatoma: Experience with cis-platinum-based chemoradiotherapy in 76 patients [J].
Abrams, RA ;
Cardinale, RM ;
Enger, C ;
Haulk, TL ;
Hurwitz, H ;
Osterman, F ;
Sitzmann, JV .
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, 1997, 39 (05) :1077-1085
[2]   TRANSFORMING GROWTH FACTOR-BETA-1 EXPRESSION IN IRRADIATED LIVER [J].
ANSCHER, MS ;
CROCKER, IR ;
JIRTLE, RL .
RADIATION RESEARCH, 1990, 122 (01) :77-85
[3]   Inclusion of organ deformation in dose calculations [J].
Brock, KK ;
McShan, DL ;
Ten Haken, RK ;
Hollister, SJ ;
Dawson, LA ;
Balter, JM .
MEDICAL PHYSICS, 2003, 30 (03) :290-295
[4]   Inclusion of biological factors in parallel-architecture normal-tissue complication probability model for radiation-induced liver disease [J].
Cheng, JCH ;
Liu, HS ;
Wu, JK ;
Chung, HW ;
Jan, GJ .
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, 2005, 62 (04) :1150-1156
[5]   Biologic susceptibility of hepatocellular carcinoma patients treated with radiotherapy to radiation-induced liver disease [J].
Cheng, JCH ;
Wu, JK ;
Lee, PCT ;
Liu, HS ;
Jian, JJM ;
Lin, YM ;
Sung, JL ;
Jan, GJ .
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, 2004, 60 (05) :1502-1509
[6]   Radiation-induced liver disease after three-dimensional conformal radiotherapy for patients with hepatocellular carcinoma: Dosimetric analysis and implication [J].
Cheng, JCH ;
Wu, JK ;
Huang, CM ;
Liu, HS ;
Huang, DY ;
Cheng, SH ;
Tsai, SY ;
Jian, JJM ;
Lin, YM ;
Cheng, TI ;
Horng, CF ;
Huang, AT .
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, 2002, 54 (01) :156-162
[7]   Use of principal component analysis to evaluate the partial organ tolerance of normal tissues to radiation [J].
Dawson, LA ;
Biersack, M ;
Lockwood, G ;
Eisbruch, A ;
Lawrence, TS ;
Ten Haken, RK .
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, 2005, 62 (03) :829-837
[8]   Partial volume tolerance of the liver to radiation [J].
Dawson, LA ;
Ten Haken, RK .
SEMINARS IN RADIATION ONCOLOGY, 2005, 15 (04) :279-283
[9]   The reproducibility of organ position using active breathing control (ABC) during liver radiotherapy [J].
Dawson, LA ;
Brock, KK ;
Kazanjian, S ;
Fitch, D ;
McGinn, CJ ;
Lawrence, TS ;
Ten Haken, RK ;
Balter, J .
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, 2001, 51 (05) :1410-1421
[10]  
Dawson LA, 2002, INT J RADIAT ONCOL, V53, P810, DOI 10.1016/S0360-3016(02)02846-8
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