How to Feed the Mammalian Gut Microbiota: Bacterial and Metabolic Modulation by Dietary Fibers

被引：75

作者：

Ferrario, Chiara ^{[1
]}

Statello, Rosario ^{[2
]}

Carnevali, Luca ^{[2
]}

Mancabelli, Leonardo ^{[1
]}

Milani, Christian ^{[1
]}

Mangifesta, Marta ^{[3
]}

Duranti, Sabrina ^{[1
]}

Lugli, Gabriele A. ^{[1
]}

Jimenez, Beatriz ^{[4
]}

Lodge, Samantha ^{[4
]}

Viappiani, Alice ^{[3
]}

Alessandri, Giulia ^{[1
]}

Dall'Asta, Margerita ^{[5
]}

Del Rio, Daniele ^{[5
]}

Sgoifo, Andrea

van Sinderen, Douwe ^{[6
,7
]}

Ventura, Marco ^{[1
]}

Turroni, Francesca ^{[1
]}

机构：

[1] Univ Parma, Dept Chem Life Sci & Environm Sustainabil, Lab Probiogen, Parma, Italy

[2] Univ Parma, Dept Chem Life Sci & Environm Sustainabil, Stress Physiol Lab, Parma, Italy

[3] GenProbio SRL, Parma, Italy

[4] Imperial Coll London, Dept Surg & Canc, Div Computat & Syst Med, London, England

[5] Univ Parma, Dept Food & Drug, Parma, Italy

[6] Natl Univ Ireland, APC Microbiome Inst, Cork, Ireland

[7] Natl Univ Ireland, Sch Microbiol, Cork, Ireland

来源：

FRONTIERS IN MICROBIOLOGY | 2017年 / 8卷

基金：

爱尔兰科学基金会;

关键词：

diet; microbiota; dietary fibers; rat model; acetate; succinate; HUMAN COLONIC MICROBIOTA; RESISTANT STARCH; INTESTINAL MICROBIOTA; FERMENTATION PATTERNS; RUMINOCOCCUS-BROMII; PECTIN; DEGRADATION; PREBIOTICS; HEALTH; DEFINITION;

D O I：

10.3389/fmicb.2017.01749

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

The composition of the gut microbiota of mammals is greatly influenced by diet. Therefore, evaluation of different food ingredients that may promote changes in the gut microbiota composition is an attractive approach to treat microbiota disturbances. In this study, three dietary fibers, such as inulin (I, 10%), resistant starch (RS, 10%), and citrus pectin (3%), were employed as supplements to normal chow diet of adult male rats for 2 weeks. Fecal microbiota composition and corresponding metabolite profiles were assessed before and after prebiotics supplementation. A general increase in the Bacteroidetes phylum was detected with a concurrent reduction in Firmicutes, in particular for I and RS experiments, while additional changes in the microbiota composition were evident at lower taxonomic levels for all the three substrates. Such modifications in the microbiota composition were correlated with changes in metabolic profiles of animals, in particular changes in acetate and succinate levels. This study represents a first attempt to modulate selectively the abundance and/or metabolic activity of various members of the gut microbiota by means of dietary fiber.

引用

页数：11

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