RETINAL PIGMENT EPITHELIAL CHANGES IN CHRONIC VOGT-KOYANAGI-HARADA DISEASE Fundus Autofluorescence and Spectral Domain-Optical Coherence Tomography Findings
被引:36
作者:
Vasconcelos-Santos, Daniel V.
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机构:
Doheny Eye Inst, Los Angeles, CA 90033 USA
Univ So Calif, Keck Sch Med, Dept Ophthalmol, Los Angeles, CA 90033 USA
Univ Fed Minas Gerais, Hosp Sao Geraldo HC, Belo Horizonte, MG, BrazilDoheny Eye Inst, Los Angeles, CA 90033 USA
Vasconcelos-Santos, Daniel V.
[1
,2
,3
]
Sohn, Elliott H.
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机构:
Doheny Eye Inst, Los Angeles, CA 90033 USA
Univ So Calif, Keck Sch Med, Dept Ophthalmol, Los Angeles, CA 90033 USADoheny Eye Inst, Los Angeles, CA 90033 USA
Sohn, Elliott H.
[1
,2
]
Sadda, Srinivas
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机构:
Doheny Eye Inst, Los Angeles, CA 90033 USA
Univ So Calif, Keck Sch Med, Dept Ophthalmol, Los Angeles, CA 90033 USADoheny Eye Inst, Los Angeles, CA 90033 USA
Sadda, Srinivas
[1
,2
]
Rao, Narsing A.
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机构:
Doheny Eye Inst, Los Angeles, CA 90033 USA
Univ So Calif, Keck Sch Med, Dept Ophthalmol, Los Angeles, CA 90033 USADoheny Eye Inst, Los Angeles, CA 90033 USA
Rao, Narsing A.
[1
,2
]
机构:
[1] Doheny Eye Inst, Los Angeles, CA 90033 USA
[2] Univ So Calif, Keck Sch Med, Dept Ophthalmol, Los Angeles, CA 90033 USA
Purpose: The purpose of this study was to determine whether fundus autofluorescence (FAF) and spectral domain-optical coherence tomography (SD-OCT) imaging allow better assessment of retinal pigment epithelium and the outer retina in subjects with chronic Vogt-Koyanagi-Harada disease compared with examination and angiography alone. Methods: A cross-sectional analysis of a series of seven consecutive patients with chronic Vogt-Koyanagi-Harada disease undergoing FAF and SD-OCT was conducted. Chronic disease was defined as duration of intraocular inflammation >3 months. Color fundus photographs were correlated to FAF and SD-OCT images. The images were later correlated to fluorescein angiography and indocyanine green angiography. Results: All patients had sunset glow fundus, which resulted in no apparent corresponding abnormality on FAF or SD-OCT. Lesions with decreased autofluorescence signal were observed in 11 eyes (85%), being associated with loss of the retinal pigment epithelium and involvement of the outer retina on SD-OCT. In 5 eyes (38%), some of these lesions were very subtle on clinical examination but easily detected by FAF. Lesions with increased autofluorescence signal were seen in 8 eyes (61.5%), showing variable involvement of the outer retina on SD-OCT and corresponding clinically to areas of retinal pigment epithelium proliferation and cystoid macular edema. Conclusion: Combined use of FAF and SD-OCT imaging allowed noninvasive delineation of retinal pigment epithelium/outer retina changes in patients with chronic Vogt-Koyanagi-Harada disease, which were consistent with previous histopathologic reports. Some of these changes were not apparent on clinical examination. RETINA 30:33-41,2010
机构:
Institute of Medical Biometry and Informatics (IMBI), University of Heidelberg, 69120 HeidelbergInstitute of Medical Biometry and Informatics (IMBI), University of Heidelberg, 69120 Heidelberg
Deckert A.
Schmitz-Valckenberg S.
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机构:
Department of Ophthalmology, University Eye Hospital, 53127 BonnInstitute of Medical Biometry and Informatics (IMBI), University of Heidelberg, 69120 Heidelberg
Schmitz-Valckenberg S.
Jorzik J.
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机构:
Department of Ophthalmology, University Eye Hospital, 69120 HeidelbergInstitute of Medical Biometry and Informatics (IMBI), University of Heidelberg, 69120 Heidelberg
Jorzik J.
Bindewald A.
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机构:
Department of Ophthalmology, University Eye Hospital, 53127 BonnInstitute of Medical Biometry and Informatics (IMBI), University of Heidelberg, 69120 Heidelberg
Bindewald A.
Holz F.G.
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机构:
Department of Ophthalmology, University Eye Hospital, 53127 BonnInstitute of Medical Biometry and Informatics (IMBI), University of Heidelberg, 69120 Heidelberg
Holz F.G.
Mansmann U.
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机构:
Institute of Medical Biometry and Informatics (IMBI), University of Heidelberg, 69120 Heidelberg
Institute of Medical Information, Biometry, and Epidemiology (IBE), University of Munich, 81377 MunichInstitute of Medical Biometry and Informatics (IMBI), University of Heidelberg, 69120 Heidelberg
机构:
Institute of Medical Biometry and Informatics (IMBI), University of Heidelberg, 69120 HeidelbergInstitute of Medical Biometry and Informatics (IMBI), University of Heidelberg, 69120 Heidelberg
Deckert A.
Schmitz-Valckenberg S.
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h-index: 0
机构:
Department of Ophthalmology, University Eye Hospital, 53127 BonnInstitute of Medical Biometry and Informatics (IMBI), University of Heidelberg, 69120 Heidelberg
Schmitz-Valckenberg S.
Jorzik J.
论文数: 0引用数: 0
h-index: 0
机构:
Department of Ophthalmology, University Eye Hospital, 69120 HeidelbergInstitute of Medical Biometry and Informatics (IMBI), University of Heidelberg, 69120 Heidelberg
Jorzik J.
Bindewald A.
论文数: 0引用数: 0
h-index: 0
机构:
Department of Ophthalmology, University Eye Hospital, 53127 BonnInstitute of Medical Biometry and Informatics (IMBI), University of Heidelberg, 69120 Heidelberg
Bindewald A.
Holz F.G.
论文数: 0引用数: 0
h-index: 0
机构:
Department of Ophthalmology, University Eye Hospital, 53127 BonnInstitute of Medical Biometry and Informatics (IMBI), University of Heidelberg, 69120 Heidelberg
Holz F.G.
Mansmann U.
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h-index: 0
机构:
Institute of Medical Biometry and Informatics (IMBI), University of Heidelberg, 69120 Heidelberg
Institute of Medical Information, Biometry, and Epidemiology (IBE), University of Munich, 81377 MunichInstitute of Medical Biometry and Informatics (IMBI), University of Heidelberg, 69120 Heidelberg