RETINAL PIGMENT EPITHELIAL CHANGES IN CHRONIC VOGT-KOYANAGI-HARADA DISEASE Fundus Autofluorescence and Spectral Domain-Optical Coherence Tomography Findings

被引:36
作者
Vasconcelos-Santos, Daniel V. [1 ,2 ,3 ]
Sohn, Elliott H. [1 ,2 ]
Sadda, Srinivas [1 ,2 ]
Rao, Narsing A. [1 ,2 ]
机构
[1] Doheny Eye Inst, Los Angeles, CA 90033 USA
[2] Univ So Calif, Keck Sch Med, Dept Ophthalmol, Los Angeles, CA 90033 USA
[3] Univ Fed Minas Gerais, Hosp Sao Geraldo HC, Belo Horizonte, MG, Brazil
来源
RETINA-THE JOURNAL OF RETINAL AND VITREOUS DISEASES | 2010年 / 30卷 / 01期
关键词
fundus autofluorescence; retinal pigment epithelium; spectral domain-optical coherence tomography; Vogt-Koyanagi-Harada disease; uveitis; CHOROIDAL-NEOVASCULARIZATION; MACULAR DEGENERATION;
D O I
10.1097/IAE.0b013e3181c5970d
中图分类号
R77 [眼科学];
学科分类号
100212 ;
摘要
Purpose: The purpose of this study was to determine whether fundus autofluorescence (FAF) and spectral domain-optical coherence tomography (SD-OCT) imaging allow better assessment of retinal pigment epithelium and the outer retina in subjects with chronic Vogt-Koyanagi-Harada disease compared with examination and angiography alone. Methods: A cross-sectional analysis of a series of seven consecutive patients with chronic Vogt-Koyanagi-Harada disease undergoing FAF and SD-OCT was conducted. Chronic disease was defined as duration of intraocular inflammation >3 months. Color fundus photographs were correlated to FAF and SD-OCT images. The images were later correlated to fluorescein angiography and indocyanine green angiography. Results: All patients had sunset glow fundus, which resulted in no apparent corresponding abnormality on FAF or SD-OCT. Lesions with decreased autofluorescence signal were observed in 11 eyes (85%), being associated with loss of the retinal pigment epithelium and involvement of the outer retina on SD-OCT. In 5 eyes (38%), some of these lesions were very subtle on clinical examination but easily detected by FAF. Lesions with increased autofluorescence signal were seen in 8 eyes (61.5%), showing variable involvement of the outer retina on SD-OCT and corresponding clinically to areas of retinal pigment epithelium proliferation and cystoid macular edema. Conclusion: Combined use of FAF and SD-OCT imaging allowed noninvasive delineation of retinal pigment epithelium/outer retina changes in patients with chronic Vogt-Koyanagi-Harada disease, which were consistent with previous histopathologic reports. Some of these changes were not apparent on clinical examination. RETINA 30:33-41,2010
引用
收藏
页码:33 / 41
页数:9
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