Point-of-use water filtration reduces healthcare-associated infections in bone marrow transplant recipients

被引:22
作者
Cervia, J. S. [1 ,2 ,3 ]
Farber, B. [1 ]
Armellino, D. [1 ]
Klocke, J. [1 ]
Bayer, R. -L. [1 ]
McAlister, M. [3 ]
Stanchfield, I. [3 ]
Canonica, F. P. [3 ]
Ortolano, G. A. [3 ]
机构
[1] N Shore Univ Hosp, Manhasset, NY 11030 USA
[2] Albert Einstein Coll Med, Bronx, NY 10467 USA
[3] Pall Med, E Hills, NY USA
关键词
point-of-use filtration; healthcare-associated infection; bone marrow transplantation; waterborne pathogens; gram-negative bacteria; infection control; biofilm; BACTERIAL BIOFILMS; POTABLE WATER; PREVENTION; LEGIONELLA; SYSTEMS; FILTER;
D O I
10.1111/j.1399-3062.2009.00459.x
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
P>Outbreaks of infection with gram-negative bacteria (GNB) have been linked to hospital water. We sought to determine whether point-of-use (POU) water filtration might result in decreased risk of infection in hospitalized bone marrow transplant (BMT) recipients in the absence of any recognized outbreak. Unfiltered water was sampled from taps in the BMT unit of a major US teaching hospital, and cultured at a reference laboratory. POU bacterial-retentive filters (0.2 mu m) were installed throughout the unit, and replaced every 14 days. Infection rates were tracked over a 9-month period, and compared with rates for a 16-month period before POU filtration. Unfiltered water samples from 50% (2 of 4) outlets sampled grew P. aeruginosa (2 of 4) and Stenotrophomonas maltophilia (1 of 4). Clinical infection rates in the unit were significantly reduced from 1.4 total and 0.4 GNB infections per 100 patient days in the period before POU filtration to 0.18 total and 0.09 GNB infections per 100 patient days (P=0.0068 and 0.0431, respectively) in the 9-month period for which filters were in place. Infections during the POU filtration period were due to non-waterborne organisms. Point-of-use (POU) water filtration may significantly reduce infection rates in BMT recipients in the absence of any recognized outbreak.
引用
收藏
页码:238 / 241
页数:4
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