Genetic mapping and ENU mutagenesis

被引：16

作者：

Beier, DR ^{[1
]}

Herron, BJ ^{[1
]}

机构：

[1] Harvard Univ, Brigham & Womens Hosp, Sch Med, Div Genet, Boston, MA 02115 USA

来源：

GENETICA | 2004年 / 122卷 / 01期

关键词：

ENU; haplotype mapping; interval mapping; mapping a phenotypic trait; mouse mutagenesis;

D O I：

10.1007/s10709-004-1437-5

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

ENU mutagenesis is a potent means to generate novel mutations in the mouse, and the further investigation of these mutations can be logistically demanding. Determination of the map position of a mutation early in its characterization can be extremely useful. We describe how the use of interval haplotype analysis can facilitate this with even small numbers of affected progeny.

引用

页码：65 / 69

页数：5

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