Substituent-regulated highly X-ray sensitive Os(VI) nitrido complex for low-toxicity radiotherapy

被引：24

作者：

Chen, Mingkai ^{[1
]}

Huang, Xiaoting ^{[1
]}

Lai, Jie ^{[1
]}

Ma, Li ^{[1
]}

Chen, Tianfeng ^{[1
]}

机构：

[1] Jinan Univ, Dept Chem, Guangzhou 510632, Peoples R China

来源：

CHINESE CHEMICAL LETTERS | 2021年 / 32卷 / 01期

关键词：

Os(VI) nitrido; Complex; Radiotherapy; Radiosensitizer; G2/M cell cycle arrest; CANCER; MITOCHONDRIA; CHEMOTHERAPY; RUTHENIUM; THERAPY; DESIGN; CELLS;

D O I：

10.1016/j.cclet.2020.11.050

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A high efficiency and low toxicity radiosensitizer, OsN(PhenOH)Cl-3, was designed and synthesized through substituent regulation. To the best of our knowledge, this is the first osmium-based coordination complex radiosensitizer. The experimental results shown that this radiosensitizer induced G2/M cell cycle arrest mainly through induction of intracellular ROS overproduction. (C) 2020 Chinese Chemical Society and Institute of Materia Medica, Chinese Academy of Medical Sciences. Published by Elsevier B.V. All rights reserved.

引用

页码：158 / 161

页数：4

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