Synthesis of Well-Defined Thermoresponsive Polyphosphoester Macroinitiators Using Organocatalysts

被引:109
作者
Iwasaki, Yasuhiko [1 ]
Yamaguchi, Etsuko [1 ]
机构
[1] Kansai Univ, Fac Chem Mat & Bioengn, Dept Chem & Mat Engn, Suita, Osaka 5648680, Japan
关键词
RING-OPENING POLYMERIZATION; POLY(ALKYLENE PHOSPHATES); BIOMEDICAL APPLICATIONS; CYCLIC ESTERS; SIDE-CHAINS; POLYMERS; PHOSPHORYLCHOLINE; TRANSESTERIFICATION;
D O I
10.1021/ma100242s
中图分类号
O63 [高分子化学(高聚物)];
学科分类号
070305 ; 080501 ; 081704 ;
摘要
A study was conducted to demonstrate the synthesis of well-defined polyphosphoesters with a narrow molecular weight distribution and a high molecular weight using organocatalysts. Block copolymers with 2-methacryloyloxyethylphosphorylcholine (MPC) were also synthesized by using poly(2-isopropoxy-2-oxo-1,3,2-dioxaphospholane) (PIPP) as a macroinitiator. PIPP was synthesized by ring-opening polymerization (ROP) using an organocatalyst as an initiator in the presence of of HEBB. A given amount of organocatalyst was introduced and polymerization was carried out at 0 °C. The mechanism of ROP with organocatalysts was characterized using 1H NMR by the researchers.
引用
收藏
页码:2664 / 2666
页数:3
相关论文
共 26 条
  • [1] EDMUNDSON RS, 1962, CHEM IND-LONDON, P1828
  • [2] Phosphorylcholine-containing polymers for biomedical applications
    Iwasaki, Y
    Ishihara, K
    [J]. ANALYTICAL AND BIOANALYTICAL CHEMISTRY, 2005, 381 (03) : 534 - 546
  • [3] Design of biodegradable amphiphilic polymers: Well-defined amphiphilic polyphosphates with hydrophilic graft chains via ATRP
    Iwasaki, Y
    Akiyoshi, K
    [J]. MACROMOLECULES, 2004, 37 (20) : 7637 - 7642
  • [4] Novel thermoresponsive polymers having biodegradable phosphoester backbones
    Iwasaki, Yasuhiko
    Wachiralarpphaithoon, Chookaet
    Akiyoshi, Kazunari
    [J]. MACROMOLECULES, 2007, 40 (23) : 8136 - 8138
  • [5] Thermoresponsive Polyphosphoesters Bearing Enzyme-cleavable Side Chains
    Iwasaki, Yasuhiko
    Kawakita, Takashi
    Yusa, Shin-ichi
    [J]. CHEMISTRY LETTERS, 2009, 38 (11) : 1054 - 1055
  • [6] Zwitterionic phosphorylcholine as a better ligand for stabilizing large biocompatible gold nanoparticles
    Jin, Qiao
    Xu, Jian-Ping
    Ji, Jian
    Shen, Jia-Cong
    [J]. CHEMICAL COMMUNICATIONS, 2008, (26) : 3058 - 3060
  • [7] KALUZYNSKI K, 1977, MAKROMOL CHEM, V178, P2943
  • [8] Organocatalytic ring-opening polymerization
    Kamber, Nahrain E.
    Jeong, Wonhee
    Waymouth, Robert M.
    Pratt, Russell C.
    Lohmeijer, Bas G. G.
    Hedrick, James L.
    [J]. CHEMICAL REVIEWS, 2007, 107 (12) : 5813 - 5840
  • [9] KATUIYHSKI K, 1976, MACROMOLECULES, V9, P365
  • [10] POLYMERIZATION OF CYCLIC ESTERS OF PHOSPHORIC-ACID .6. POLY(ALKYL ETHYLENE PHOSPHATES) - POLYMERIZATION OF 2-ALKOXY-2-OXO-1,3,2-DIOXAPHOSPHOLANS AND STRUCTURE OF POLYMERS
    LIBISZOWSKI, J
    KALUZYNSKI, K
    PENCZEK, S
    [J]. JOURNAL OF POLYMER SCIENCE PART A-POLYMER CHEMISTRY, 1978, 16 (06) : 1275 - 1283