The emergence of a novel ceftazidime-resistant CTX-M extended-spectrum β-lactamase, CTX-M-55, in both community-onset and hospital-acquired infections in Thailand

被引:100
作者
Kiratisin, Pattarachai [1 ]
Apisarnthanarak, Anucha
Saifon, Piyawan
Laesripa, Chaitat
Kitphati, Rungrueng
Mundy, Linda M.
机构
[1] Mahidol Univ, Fac Med, Dept Microbiol, Siriraj Hosp, Bangkok 10700, Thailand
[2] Thammasart Univ Hosp, Div Infect Dis, Fac Med, Pathum Thani 12120, Thailand
[3] Thai Natl Inst Hlth, Dept Sci, Nonthaburi 11000, Thailand
[4] St Louis Univ, Sch Publ Hlth, St Louis, MO 63110 USA
关键词
extended-spectrum beta-lactamase; ESBL; Escherichia coli; Klebsiella pneumoniae;
D O I
10.1016/j.diagmicrobio.2007.02.005
中图分类号
R51 [传染病];
学科分类号
100401 ;
摘要
We report a novel CTX-M type of extended-spectrum beta-lactamase (ESBL), designated CTX-M-55, among 7 patients who had infection with ESBL-producing Escherichia coli or Klebsiella pneumoniae at a university hospital in Thailand. The CTX-M-55 ESBL showed reduced susceptibility to ceftazidime. This investigation provides the relevant clinical and molecular epidemiology for the gene encoding for CTX-M-55 in the isolates from these patients. (c) 2007 Elsevier Inc. All rights reserved.
引用
收藏
页码:349 / 355
页数:7
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