The composition of Ehrlich's salvarsan: Resolution of a century-old debate

被引：169

作者：

Lloyd, NC

Morgan, HW

Nicholson, BK

Ronimus, RS

机构：

[1] Univ Waikato, Dept Chem, Hamilton, New Zealand

[2] Univ Waikato, Dept Biol Sci, Hamilton, New Zealand

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2005年 / 44卷 / 06期

关键词：

arsenic; arsphenamine; mass spectrometry; salvarsan; structure elucidation;

D O I：

10.1002/anie.200461471

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Elusive molecular structure revealed: The primary components of the historically important pharmaceutical compound salvarsan (arsphenamine, Ehrlich 606) have been shown by ESI mass spectrometry to be cyclopolyarsines [RAs] n (see structure; n = 3-6 and R = 3-amino-4-hydroxyphenyl).

引用

页码：941 / 944

页数：4

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