Gold Nanoparticles Bearing a Tumor pH-Sensitive Cyclodextrin Cap

被引:26
作者
Koo, Mijin [1 ]
Oh, Kyung Taek [2 ]
Noh, Gwangjin [1 ]
Lee, Eun Seong [1 ]
机构
[1] Catholic Univ Korea, Dept Biotechnol, 43 Jibong Ro, Bucheon Si 14662, Gyeonggi Do, South Korea
[2] Chung Ang Univ, Coll Pharm, 84 Heukseok Ro, Seoul 06974, South Korea
基金
新加坡国家研究基金会;
关键词
gold nanoparticles; pH-sensitive cyclodextrin cap; tumor acidic pH; photothermal therapy; photodynamic therapy; PHOTODYNAMIC THERAPY; RECENT PROGRESS; PENETRATION; MICROENVIRONMENT; NANOTECHNOLOGY; NANOCLUSTERS; RELEASE; CANCER;
D O I
10.1021/acsami.8b08595
中图分类号
TB3 [工程材料学];
学科分类号
0805 ; 080502 ;
摘要
We report functional gold nanoparticles (AuNPs) with a pH-sensitive gamma-cyclodextrin (CD) cap. These particles include two chargeable CD molecules on their surface. CD with dopamine and amine (NH2) groups (hereafter termed as dCD-NH2) was anchored to the gold surface and then electrostatically complexed with the CD with 2,3-dimethylmaleic acid (DMA) and chlorin e6 (Ce6) (hereafter termed as cCD-DMA), producing an ionic complex consisting of dCD-NH2 and cCD-DMA. Under the acidic environment (pH 6.8) existing in most solid tumors, the ionic complex was destabilized because of the decoupling of DMA, resulting in the release of cCD (without DMA) from the AuNPs, resulting in extensive tumoral uptake of AuNPs with dCD-NH2 (because of their electrostatic attraction to tumor cells). This event resulted in a significant increase in the efficiency of cellular AuNP uptake and light-driven (AuNP-mediated photothermal and Ce6-mediated photodynamic) ablation of acidic solid tumors, suggesting marked potential for tumor therapy.
引用
收藏
页码:24450 / 24458
页数:9
相关论文
共 29 条
[1]   Dual-Energy CT Imaging of Tumor Liposome Delivery After Gold Nanoparticle-Augmented Radiation Therapy [J].
Ashton, Jeffrey R. ;
Castle, Katherine D. ;
Qi, Yi ;
Kirsch, David G. ;
West, Jennifer L. ;
Badea, Cristian T. .
THERANOSTICS, 2018, 8 (07) :1782-1797
[2]   Cancer nanotechnology: The impact of passive and active targeting in the era of modern cancer biology [J].
Bertrand, Nicolas ;
Wu, Jun ;
Xu, Xiaoyang ;
Kamaly, Nazila ;
Farokhzad, Omid C. .
ADVANCED DRUG DELIVERY REVIEWS, 2014, 66 :2-25
[3]   Functional Nanomaterials for Phototherapies of Cancer [J].
Cheng, Liang ;
Wang, Chao ;
Feng, Liangzhu ;
Yang, Kai ;
Liu, Zhuang .
CHEMICAL REVIEWS, 2014, 114 (21) :10869-10939
[4]   A Simple Spectroscopic Method for Differentiating Cellular Uptakes of Gold Nanospheres and Nanorods from Their Mixtures [J].
Cho, Eun Chul ;
Liu, Yang ;
Xia, Younan .
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2010, 49 (11) :1976-1980
[5]   The EPR effect: Unique features of tumor blood vessels for drug delivery, factors involved, and limitations and augmentation of the effect [J].
Fang, Jun ;
Nakamura, Hideaki ;
Maeda, Hiroshi .
ADVANCED DRUG DELIVERY REVIEWS, 2011, 63 (03) :136-151
[6]   Au Nanoclusters and Photosensitizer Dual Loaded Spatiotemporal Controllable Liposomal Nanocomposites Enhance Tumor Photodynamic Therapy Effect by Inhibiting Thioredoxin Reductase [J].
Gao, Fuping ;
Zheng, Weiping ;
Gao, Liang ;
Cai, Pengju ;
Liu, Ru ;
Wang, Yaling ;
Yuan, Qing ;
Zhao, Yuliang ;
Gao, Xueyun .
ADVANCED HEALTHCARE MATERIALS, 2017, 6 (07)
[7]   Recent progress in theranostic applications of hybrid gold nanoparticles [J].
Gharatape, Alireza ;
Salehi, Roya .
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2017, 138 :221-233
[8]   MRI of the tumor microenvironment [J].
Gillies, RJ ;
Raghunand, N ;
Karczmar, GS ;
Bhujwalla, ZM .
JOURNAL OF MAGNETIC RESONANCE IMAGING, 2002, 16 (04) :430-450
[9]   Enzyme-triggered size shrink and laser-enhanced NO release nanoparticles for deep tumor penetration and combination therapy [J].
Hu, Chuan ;
Cun, Xingli ;
Ruan, Shaobo ;
Liu, Rui ;
Xiao, Wei ;
Yang, Xiaotong ;
Yang, Yuanyuan ;
Yang, Chuanyao ;
Gao, Huile .
BIOMATERIALS, 2018, 168 :64-75
[10]   Gold Nanorod-Photosensitizer Complex for Near-Infrared Fluorescence Imaging and Photodynamic/Photothermal Therapy In Vivo [J].
Jang, Boseung ;
Park, Jin-Young ;
Tung, Ching-Hsuan ;
Kim, In-Hoo ;
Choi, Yongdoo .
ACS NANO, 2011, 5 (02) :1086-1094