AE36 HER2/neu-derived peptide linked to positively charged liposomes with CpG-ODN as an effective therapeutic and prophylactic vaccine for breast cancer

被引：6

作者：

Barati, Nastaran ^{[1
,2
]}

Mosaffa, Fatemeh ^{[4
]}

Razazan, Atefeh ^{[5
]}

Badiee, Ali ^{[4
]}

Behravan, Javad ^{[4
,8
,9
]}

Nikpoor, Amin Reza ^{[3
]}

Motavallihaghi, Seyed Mousa ^{[7
]}

Jaafari, Mahmoud Reza ^{[4
,6
,10
]}

机构：

[1] Hamadan Univ Med Sci, Vice Chancellor Res & Technol, Hamadan, Iran

[2] Hamadan Univ Med Sci, Med Plants & Nat Prod Res Ctr, Hamadan, Iran

[3] Hormozgan Univ Med Sci, Hormozgan Hlth Inst, Mol Med Res Ctr, Bandar Abbas, Iran

[4] Mashhad Univ Med Sci, Sch Pharm, Mashhad, Iran

[5] Univ Tehran Med Sci, Sch Adv Technol Med, Dept Mol Med, Tehran, Iran

[6] Mashhad Univ Med Sci, Pharmaceut Technol Inst, Nanotechnol Res Ctr, Mashhad, Iran

[7] Hamadan Univ Med Sci, Sch Med, Dept Med Parasitol & Mycol, Hamadan, Iran

[8] Mediphage Bioceut Inc, MaRS Ctr, Toronto, ON, Canada

[9] Mashhad Univ Med Sci, MaRS Ctr, Sch Pharm, Mediphage Bioceut Inc, POB 91775-1365, Toronto, ON, Canada

[10] Mashhad Univ Med Sci, Mashhad Univ Med Sci, Pharmaceut Technol Inst, Biotechnol Res Ctr, POB 91775-1365, Mashhad, Iran

来源：

JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY | 2022年 / 67卷

关键词：

AE36 HER2/Neu-derived peptide; Nanoliposomes; CpG-ODN; Vaccine; Cancer; MICE TUBO MODEL; T-CELL; ESTABLISHED TUMORS; IMMUNITY; HER-2; ACTIVATION; RESPONSES; CD4(+); SYSTEM;

D O I：

10.1016/j.jddst.2021.102904

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

In the present day and age, cancer is still a life-limiting factor whose one of the therapeutic strategies is immunotherapy with vaccines. This research aims to prepare and characterize nanoliposomal vaccine formu-lation attached to HER2/neu-derived peptide (AE36) with or without CpG-ODN, and to evaluate its immuno-logical responses to the therapy using BALB/c mice with HER2 overexpressing breast cancer. AE36 was conjugated to the liposomes containing DOTAP, DOPE and Cholesterol. Such formulations are able to produce CD8(+) and CD4(+) responses and induce synthesis of cytokines detectable via Enzyme-linked immunosorbent assay kits, cytotoxicity testing and intracellular cytokine staining combine.

引用

页数：8

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