New embo member's review - Dendritic cell regulation of immune responses: a new role for interleukin 2 at the intersection of innate and adaptive immunity

被引：92

作者：

Granucci, F ^{[1
]}

Zanoni, I ^{[1
]}

Feau, S ^{[1
]}

Ricciardi-Castagnoli, P ^{[1
]}

机构：

[1] Univ Milano Bicocca, Dept Biotechnol & Biosci, Milan, Italy

来源：

EMBO JOURNAL | 2003年 / 22卷 / 11期

关键词：

adaptive immune response; dendritic cells; innate immune response; interleukin; 2; regulatory T cells;

D O I：

10.1093/emboj/cdg261

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Dendritic cells are professional antigen-presenting cells able to initiate innate and adaptive immune responses against invading pathogens. In response to external stimuli dendritic cells undergo a complete genetic reprogramming that allows them to become, soon after activation, natural killer cell activators and subsequently T cell stimulators. The recent observation that dendritic cells produce interleukin 2 following microbial stimulation opens new possibilities for understanding the efficiency of dendritic cells in regulating immune system functions. This review discusses how dendritic cells control natural killer, T- and B-cell responses and the relevance of interleukin 2 in these processes.

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页码：2546 / 2551

页数：6

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