CaSiAn: a Calcium Signaling Analyzer tool

被引：11

作者：

Moein, Mahsa ^{[1
]}

Grzyb, Kamil ^{[1
]}

Martins, Teresa Goncalves ^{[1
]}

Komoto, Shinya ^{[2
]}

Peri, Francesca ^{[3
]}

Crawford, Alexander D. ^{[1
]}

d'Herouel, Aymeric Fouquier ^{[1
]}

Skupin, Alexander ^{[1
,4
]}

机构：

[1] Univ Luxembourg, Luxembourg Ctr Syst Biomed, L-4367 Belvaux, Luxembourg

[2] Okinawa Inst Sci & Technol Grad Univ, Onna 9040495, Japan

[3] EMBL, Dev Biol Unit, D-69117 Heidelberg, Germany

[4] Univ Calif San Diego, La Jolla, CA 92093 USA

来源：

BIOINFORMATICS | 2018年 / 34卷 / 17期

基金：

美国国家卫生研究院;

关键词：

DYNAMICS;

D O I：

10.1093/bioinformatics/bty281

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

The Summary: Ca2+ is a central second messenger in eukaryotic cells that regulates many cellular processes. Recently, we have indicated that typical Ca2+ signals are not purely oscillatory as widely assumed, but exhibit stochastic spiking with cell type and pathway specific characteristics. Here, we present the Calcium Signaling Analyzer (CaSiAn), an open source software tool that allows for quantifying these signal characteristics including individual spike properties and time course statistics in a semi-automated manner. CaSiAn provides an intuitive graphical user interface allowing experimentalists to easily process a large amount of Ca2+ signals, interactively tune peak detection, revise statistical measures and access the quantified signal properties as excel or text files.

引用

页码：3052 / 3054

页数：3

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