Rationale and Design for an Investigation to Optimize Selective Serotonin Reuptake Inhibitor Treatment for Pregnant Women with Depression

被引：13

作者：

Avram, M. J. ^{[1
]}

Stika, C. S. ^{[2
]}

Rasmussen-Torvik, L. J. ^{[3
]}

Ciolino, J. D. ^{[3
]}

Pinheiro, E. ^{[4
]}

George, A. L., Jr. ^{[5
]}

Wisner, K. L. ^{[4
]}

机构：

[1] Northwestern Univ, Feinberg Sch Med, Dept Anesthesiol, Chicago, IL 60611 USA

[2] Northwestern Univ, Dept Obstet & Gynecol, Feinberg Sch Med, Chicago, IL 60611 USA

[3] Northwestern Univ, Dept Prevent Med, Feinberg Sch Med, Chicago, IL 60611 USA

[4] Northwestern Univ, Dept Psychiat & Behav Sci, Feinberg Sch Med, Chicago, IL 60611 USA

[5] Northwestern Univ, Dept Pharmacol, Feinberg Sch Med, Chicago, IL 60611 USA

来源：

CLINICAL PHARMACOLOGY & THERAPEUTICS | 2016年 / 100卷 / 01期

关键词：

D O I：

10.1002/cpt.375

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The physiological changes of pregnancy can affect the pharmacokinetics of a drug, thereby affecting its dose requirements. Because pharmacokinetic (PK) studies in pregnant women have rarely been conducted, evidence-based dosing adjustments are seldom available. In particular, despite the fact that the use of antidepressants has become increasingly common, pregnancy-associated PK changes of the selective serotonin reuptake inhibitors (SSRIs) are largely unknown.

引用

页码：31 / 33

页数：3

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