Regulation of telomerase activity by apparently opposing elements

被引：44

作者：

Liu, Jun-Ping ^{[1
]}

Chen, Shi-Ming ^{[2
,3
]}

Cong, Yu-Sheng ^{[4
]}

Nicholls, Craig ^{[1
]}

Zhou, Shu-Feng ^{[5
]}

Tao, Ze-Zhang ^{[2
,3
]}

Li, He ^{[1
]}

机构：

[1] Monash Univ, Mol Signaling Lab, Dept Immunol, Cent Clin Sch,AMREP, Melbourne, Vic 3004, Australia

[2] Wuhan Univ, Otolaryngol Head Neck Inst, Wuhan 430060, Hubei, Peoples R China

[3] Wuhan Univ, Renmin Hosp, Wuhan 430060, Hubei, Peoples R China

[4] Beijing Normal Univ, Coll Life Sci, Inst Cell Biol, Beijing 100875, Peoples R China

[5] RMIT Univ, Sch Hlth Sci, Bundoora, Vic 3083, Australia

来源：

AGEING RESEARCH REVIEWS | 2010年 / 9卷 / 03期

基金：

中国国家自然科学基金; 英国医学研究理事会;

关键词：

Telomerase; Gene expression; Regulation; Cancer; ACUTE PROMYELOCYTIC LEUKEMIA; TRANS-RETINOIC ACID; GROWTH-FACTOR-BETA; BONE MORPHOGENETIC PROTEIN-7; REVERSE-TRANSCRIPTASE HTERT; CD8(+) T-CELLS; 15-DEOXY-DELTA(12,14)-PROSTAGLANDIN J(2)-INDUCED APOPTOSIS; SYNERGISTIC DOWN-REGULATION; TYROSINE KINASE INHIBITOR; ESTROGEN-RECEPTOR-ALPHA;

D O I：

10.1016/j.arr.2010.03.002

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Telomeres, the ends of chromosomes, undergo frequent remodeling events that are important in cell development, proliferation and differentiation, and neoplastic immortalization. It is not known how the cellular environment influences telomere remodeling, stability, and lengthening or shortening. Telomerase is a ribonucleoprotein complex that maintains and lengthens telomeres in the majority of cancers. Recent studies indicate that a number of factors, including hormones, cytokines, ligands of nuclear receptor, vitamins and herbal extracts have significantly influence telomerase activity and, in some instances, the remodeling of telomeres. This review summarizes the advances in understanding of the positive and negative regulation by extracellular factors of telomerase activity in cancer, stem cells and other systems in mammals. (C) 2010 Elsevier Ireland Ltd. All rights reserved.

引用

页码：245 / 256

页数：12

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