Anaplastic transformation in lung metastases of differentiated papillary thyroid carcinoma: an autopsy case report and review of the literature

被引:12
作者
Al-Qsous, Wael [1 ]
Miller, Iain D. [1 ]
机构
[1] Aberdeen Royal Infirm, Dept Pathol, Aberdeen AB25 2ZD, Scotland
关键词
Thyroid; Papillary carcinoma; Anaplastic transformation;
D O I
10.1016/j.anndiagpath.2009.04.003
中图分类号
R36 [病理学];
学科分类号
100104 ;
摘要
Anaplastic transformation of papillary thyroid carcinoma is a rare condition and is associated with an aggressive behavior. Most cases described in the literature have occurred in the thyroid gland or in the surrounding cervical lymph nodes. We report a case of an 83-year-old man who, 10 years after being treated for a conventional papillary thyroid carcinoma, presented with widespread metastases in his lungs. At autopsy, he was found to have extensive metastatic deposits in both lungs, which histologically and immunohistochemically were consistent with papillary thyroid carcinoma. An unusual finding was the presence of solid pleomorphic foci within tumor deposits, consistent with anaplastic transformation. (C) 2010 Elsevier Inc. All rights reserved.
引用
收藏
页码:41 / 43
页数:3
相关论文
共 13 条
[1]   Papillary thyroid carcinoma with an uncommon spread of hematogenous metastases to the choroid and the skin [J].
Bucerius, Jan ;
Meyka, Susanne ;
Bangard, Michael ;
Biersack, Hans-Juergen ;
Eter, Nicole .
JOURNAL OF THE NATIONAL MEDICAL ASSOCIATION, 2008, 100 (01) :104-107
[2]   Simultaneous medullary and papillary thyroid cancer: Two case reports [J].
Dionigi G. ;
Castano P. ;
Bertolini V. ;
Boni L. ;
Rovera F. ;
Tanda M.L. ;
Capella C. ;
Bartalena L. ;
Dionigi R. .
Journal of Medical Case Reports, 1 (1)
[3]  
MAITRA A, 2005, ENDOCRINE SYSTEM ROB, P1177
[4]  
NUSSBAUM M, 1981, CANCER-AM CANCER SOC, V48, P2724, DOI 10.1002/1097-0142(19811215)48:12<2724::AID-CNCR2820481228>3.0.CO
[5]  
2-1
[6]   Papillary carcinoma of the thyroid with distant metastases to the cerebrum: a case report [J].
Ota, T ;
Bando, Y ;
Hirai, M ;
Tanaka, N ;
Takabatake, Y ;
Kasahara, Y ;
Fujisawa, M .
JAPANESE JOURNAL OF CLINICAL ONCOLOGY, 2001, 31 (03) :112-115
[7]  
Patel Kepal N, 2006, Cancer Control, V13, P119
[8]  
ROSAI J, 2004, THYROID GLAND ROSAI, P552
[9]   A rare case of anaplastic transformation within the metastatic site of the retroperitoneal region in a patient 17 years after total thyroidectomy for papillary carcinoma of the thyroid beginning with multiple bone metastases [J].
Sotome, Keiichi ;
Onishi, Tatsuya ;
Hirano, Atsushi ;
Nakamaru, Makoto ;
Furukawa, Akio ;
Miyazaki, Hiroshi ;
Morozumi, Kyoei ;
Tanaka, Yoichi ;
Iri, Hisami ;
Mimura, Yoshikazu .
THYROID, 2007, 17 (12) :1309-1311
[10]   A case of submandibular malignant rhabdoid tumor transformed from papillary thyroid carcinoma [J].
Sumida, T ;
Hamakawa, H ;
Imaoka, M ;
Okamoto, N ;
Takarada, M ;
Tanioka, H ;
Ueda, N ;
Nose, M .
JOURNAL OF ORAL PATHOLOGY & MEDICINE, 2001, 30 (07) :443-447