Investigating the anti-proliferative activity of styrylazanaphthalenes and azanaphthalenediones

被引：43

作者：

Mrozek-Wilczkiewicz, Anna ^{[2
,4
]}

Kalinowski, Danuta S. ^{[1
,3
]}

Musiol, Robert ^{[2
]}

Finster, Jacek ^{[2
]}

Szurko, Agnieszka ^{[4
,5
]}

Serafin, Katarzyna ^{[2
]}

Knas, Magdalena ^{[2
]}

Kamalapuram, Sishir K. ^{[1
,3
]}

Kovacevic, Zaklina ^{[1
,3
]}

Jampilek, Josef ^{[6
,7
]}

Ratuszna, Alicja ^{[4
]}

Rzeszowska-Wolny, Joanna ^{[5
]}

Richardson, Des R. ^{[1
,3
]}

Polanski, Jaroslaw ^{[2
]}

机构：

[1] Univ Sydney, Dept Pathol, Sydney, NSW 2006, Australia

[2] Univ Silesia, Inst Chem, Dept Organ Chem, PL-40006 Katowice, Poland

[3] Univ Sydney, Bosch Inst, Sydney, NSW 2006, Australia

[4] Univ Silesia, Inst Phys, Dept Solid State Phys, PL-40007 Katowice, Poland

[5] M Sklodowska Curie Mem Inst, Ctr Oncol, Dept Expt & Clin Radiobiol, PL-44101 Gliwice, Poland

[6] Zentiva AS, CZ-10237 Prague 10, Czech Republic

[7] Univ Vet & Pharmaceut Sci, Fac Pharm, Dept Chem Drugs, CZ-61242 Brno, Czech Republic

来源：

BIOORGANIC & MEDICINAL CHEMISTRY | 2010年 / 18卷 / 07期

基金：

澳大利亚研究理事会; 英国医学研究理事会;

关键词：

Anti-proliferative activity; Quinazolinone; Styrylquinazoline; BIOLOGICAL-ACTIVITY SPECTRUM; INTEGRASE INHIBITORS; ANTITUMOR-ACTIVITY; HIV-1; REPLICATION; ANALOGS; LAVENDAMYCIN; DERIVATIVES; EFFICIENT; AGENTS; ESTER;

D O I：

10.1016/j.bmc.2010.02.025

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A group of styrylazanaphthalenes and azanaphthalenediones were synthesized and tested for their anti-proliferative activity. Most of the compounds were obtained with the use of microwave-assisted synthesis. The lipophilicity of the compounds was measured by RP-HPLC and their anti-proliferative activity was assayed against the human SK-N-MC neuroepithelioma and HCT116 human colon carcinoma cell lines. Active compounds were also tested in clonogenity and comet assays. Several quinazolinone and styrylquinazoline analogues were found to have markedly greater anti-proliferative activity than desferoxamine and cis-platin. (C) 2010 Elsevier Ltd. All rights reserved.

引用

页码：2664 / 2671

页数：8

共 50 条

[31] Synthesis and anti-proliferative activity of novel azazerumbone conjugates with chalcones
Vuong Van Truong
Tran Duy Nam
Truong Ngoc Hung
Nguyen Thi Nga
Pham Minh Quan
Luu Van Chinh
Jung, Sang-Hun
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2015, 25 (22) : 5182 - 5185
[32] Fluorescent schweinfurthin B and F analogs with anti-proliferative activity
Topczewski, Joseph J.
Kuder, Craig H.
Neighbors, Jeffrey D.
Hohl, Raymond J.
Wiemer, David F.
BIOORGANIC & MEDICINAL CHEMISTRY, 2010, 18 (18) : 6734 - 6741
[33] Isochaihulactone analogues: Synthesis and anti-proliferative activity of novel dibenzylbutyrolactones
Alizadeh, Babak Heidary
Foroumadi, Alireza
Emami, Saeed
Khoobi, Mehdi
Panah, Fatemeh
Ardestani, Sussan K.
Shafiee, Abbas
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2010, 45 (12) : 5979 - 5984
[34] Dischidia nummularia - a potential plant for cytotoxicity and anti-proliferative activity
Khalil-ur-Rehman, M.
Wenzig, Pferschy E. M.
Kretschmer, N.
Kunert, O.
Hofer, F.
Bauer, R.
PLANTA MEDICA, 2019, 85 (18) : 1525 - 1526
[35] Anti-proliferative activity of γ -glutamylcyclotransferase knockdown in colorectal cancer cells
Ii, Hiromi
Ito, Kosei
Nakata, Susumu
CANCER SCIENCE, 2023, 114 : 536 - 536
[36] Anti-proliferative activity of apigenin in colorectal and breast cancer cells
Krisanapun, Chutwadee
Lee, Seong-Ho
Perez-Albela, Luis
Sams, Carl
Peungvicha, Penchom
Baek, Seung
CANCER RESEARCH, 2009, 69
[37] Preliminary in vitro evaluation of the anti-proliferative activity of guanylhydrazone derivatives
Franca, Paulo H. B.
Da Silva-Junior, Edeildo F.
Aquino, Pedro G. V.
Santana, Antonio E. G.
Ferro, Jamylle N. S.
Barreto, Emiliano De Oliveira
Pessoa, Claudia Do O.
Meira, Assuero Silva
De Aquino, Thiago M.
Alexandre-Moreira, Magna S.
Schmitt, Martine
De Araujo-Junior, Joao X.
ACTA PHARMACEUTICA, 2016, 66 (01) : 129 - 137
[38] The Antioxidant and Anti-proliferative Activity of the Lebanese Olea europaea Extract
Fares, Rida
Bazzi, Samer
Baydoun, Serine E.
Abdel-Massih, Roula M.
PLANT FOODS FOR HUMAN NUTRITION, 2011, 66 (01) : 58 - 63
[39] Analogues of the Inhoffen-Lythgoe diol with anti-proliferative activity
DeBerardinis, Albert M.
Lemieux, Steven
Hadden, M. Kyle
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2013, 23 (19) : 5367 - 5370
[40] Anti-proliferative activity of dithiocarbamate salts: Synthesis and in vitro study
Abu Deiab, Ghina'a
Hmedat, Ali
El-khateeb, Mohammad
Tahtamouni, Lubna
Quraan, Lama
Alsakhen, Mai
Alabbas, Nour
Aldhirat, Joman
Talib, Wamidh
CHEMICAL PAPERS, 2025, 79 (01) : 123 - 131

← 1 2 3 4 5 →