Investigating the anti-proliferative activity of styrylazanaphthalenes and azanaphthalenediones

被引：43
|
作者：
Mrozek-Wilczkiewicz, Anna [2 ,4 ]
Kalinowski, Danuta S. [1 ,3 ]
Musiol, Robert [2 ]
Finster, Jacek [2 ]
Szurko, Agnieszka [4 ,5 ]
Serafin, Katarzyna [2 ]
Knas, Magdalena [2 ]
Kamalapuram, Sishir K. [1 ,3 ]
Kovacevic, Zaklina [1 ,3 ]
Jampilek, Josef [6 ,7 ]
Ratuszna, Alicja [4 ]
Rzeszowska-Wolny, Joanna [5 ]
Richardson, Des R. [1 ,3 ]
Polanski, Jaroslaw [2 ]
机构：
[1] Univ Sydney, Dept Pathol, Sydney, NSW 2006, Australia
[2] Univ Silesia, Inst Chem, Dept Organ Chem, PL-40006 Katowice, Poland
[3] Univ Sydney, Bosch Inst, Sydney, NSW 2006, Australia
[4] Univ Silesia, Inst Phys, Dept Solid State Phys, PL-40007 Katowice, Poland
[5] M Sklodowska Curie Mem Inst, Ctr Oncol, Dept Expt & Clin Radiobiol, PL-44101 Gliwice, Poland
[6] Zentiva AS, CZ-10237 Prague 10, Czech Republic
[7] Univ Vet & Pharmaceut Sci, Fac Pharm, Dept Chem Drugs, CZ-61242 Brno, Czech Republic
来源：
BIOORGANIC & MEDICINAL CHEMISTRY | 2010年 / 18卷 / 07期
基金：
英国医学研究理事会; 澳大利亚研究理事会;
关键词：
Anti-proliferative activity; Quinazolinone; Styrylquinazoline; BIOLOGICAL-ACTIVITY SPECTRUM; INTEGRASE INHIBITORS; ANTITUMOR-ACTIVITY; HIV-1; REPLICATION; ANALOGS; LAVENDAMYCIN; DERIVATIVES; EFFICIENT; AGENTS; ESTER;
D O I：
10.1016/j.bmc.2010.02.025
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
A group of styrylazanaphthalenes and azanaphthalenediones were synthesized and tested for their anti-proliferative activity. Most of the compounds were obtained with the use of microwave-assisted synthesis. The lipophilicity of the compounds was measured by RP-HPLC and their anti-proliferative activity was assayed against the human SK-N-MC neuroepithelioma and HCT116 human colon carcinoma cell lines. Active compounds were also tested in clonogenity and comet assays. Several quinazolinone and styrylquinazoline analogues were found to have markedly greater anti-proliferative activity than desferoxamine and cis-platin. (C) 2010 Elsevier Ltd. All rights reserved.
引用
收藏
页码：2664 / 2671
页数：8
相关论文
共 50 条
  • [1] Synthesis and anti-proliferative activity of novel oxepin-annulated coumarins
    Prateeptongkum, Saisuree
    Mahavorasirikul, Wiratchanee
    Duangdee, Nongnaphat
    ARKIVOC, 2018, : 73 - 85
  • [2] Anti-proliferative activity of dithiocarbamate salts: Synthesis and in vitro study
    Abu Deiab, Ghina'a
    Hmedat, Ali
    El-khateeb, Mohammad
    Tahtamouni, Lubna
    Quraan, Lama
    Alsakhen, Mai
    Alabbas, Nour
    Aldhirat, Joman
    Talib, Wamidh
    CHEMICAL PAPERS, 2025, 79 (01) : 123 - 131
  • [3] CoMFA Study on Anti-proliferative Activity of Fluoroquinolone Amide Derivatives?
    Feng Hui
    Cao Jing-Pei
    Feng Chang-Jun
    CHINESE JOURNAL OF STRUCTURAL CHEMISTRY, 2022, 41 (03) : 2203241 - 2203247
  • [4] Synthesis and anti-proliferative activity of novel azazerumbone conjugates with chalcones
    Vuong Van Truong
    Tran Duy Nam
    Truong Ngoc Hung
    Nguyen Thi Nga
    Pham Minh Quan
    Luu Van Chinh
    Jung, Sang-Hun
    BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2015, 25 (22) : 5182 - 5185
  • [5] Synthesis of new benzo[f]chromene-based heterocycles targeting anti-proliferative activity
    Abu El-Azm, Fatma S. M.
    El-Shahawi, Manal M.
    Elgubbi, Amna S.
    Madkour, Hassan M. F.
    JOURNAL OF THE IRANIAN CHEMICAL SOCIETY, 2021, 18 (05) : 1081 - 1092
  • [6] Chemical Constituents of Siegesbeckia orientalis and Their Anti-Proliferative Activity
    Li, Rongxian
    Ge, Di
    Yin, Wenying
    Zhang, Yongqi
    Liu, Mengjia
    Xue, Han
    Zhao, Xianshou
    Liu, Na
    RECORDS OF NATURAL PRODUCTS, 2025,
  • [7] Anti-proliferative, structure–activity relationship of pyridinylchalcones and chromanones
    Cherupally Dayakar
    Pathi Suman
    Kommera Rajkumar
    Thampunuri Ramalinga Murthy
    Shasi Vardhan Kalivendi
    Bhimapaka China Raju
    Medicinal Chemistry Research, 2018, 27 : 80 - 94
  • [8] The anti-proliferative and anti-androgenic activity of different pomegranate accessions
    Orgil, Ola
    Spector, Limor
    Holland, Down
    Mahajna, Jamal
    Amir, Rachel
    JOURNAL OF FUNCTIONAL FOODS, 2016, 26 : 517 - 528
  • [9] Synthesis and evaluation of anti-proliferative activity of 1,4-disubstituted phthalazines
    Abouzid, Khaled A. M.
    Khalil, Nadia A.
    Ahmed, Eman M.
    MEDICINAL CHEMISTRY RESEARCH, 2012, 21 (10) : 3288 - 3293
  • [10] Phenolic Profile, Antioxidant Activity and Anti-proliferative Activity of Crabapple Fruits
    Meiling Han
    Guo Li
    Xiaowei Liu
    Ai Li
    Peiqi Mao
    Pengyuan Liu
    Houhua Li
    HorticulturalPlantJournal, 2019, 5 (04) : 155 - 163
12345