Biomarkers of oxidative-stress and inflammation in exhaled breath condensate from hospital cleaners

被引：22
作者：
Casimirri, Enrico [1 ]
Stendardo, Mariarita [1 ]
Bonci, Melissa [1 ]
Andreoli, Roberta [2 ]
Bottazzi, Barbara [3 ]
Leone, Roberto [3 ]
Schito, Michela [1 ]
Vaccari, Alice [1 ]
Papi, Alberto [1 ]
Contoli, Marco [1 ]
Corradi, Massimo [2 ]
Boschetto, Piera [1 ]
机构：
[1] Univ Ferrara, Dept Med Sci, I-44100 Ferrara, Italy
[2] Univ Parma, Dept Clin & Expt Med, I-43100 Parma, Italy
[3] Ist Ricovero & Cura Carattere Sci, Ist Clin Humanitas, Rozzano, Italy
来源：
BIOMARKERS | 2016年 / 21卷 / 02期
关键词：
cleaners; Pentraxin-3; Biological effect markers; soluble interleukin-1 receptor type II; exhaled breath condensate; PENTRAXIN; 3; EXPOSURE; ASTHMA;
D O I：
10.3109/1354750X.2015.1118541
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
Objective: We studied the impact of chlorinated agents exposure on exhaled breath condensate (EBC) biomarkers in cleaners. Methods: Malondialdehyde (MDA), 4-hydroxynonenal (4-HNE), nitrites ( [GRAPHICS] ), nitrates ( [GRAPHICS] ), pH, hydrogen peroxide (H2O2) and ammonium ( [GRAPHICS] ) were tested in EBC of 40 cleaners and 40 non-exposed controls. Pentraxin-3 (PTX3) and soluble type II receptor of IL-1 (sIL-1RII) were analyzed also in plasma. Results: Levels of MDA-EBC, 4-HNE-EBC and [GRAPHICS] -EBC were higher, while pH-EBC values were lower, in cleaners. MDA-EBC was associated with 4-HNE-EBC, [GRAPHICS] -EBC and pH. 4-HNE-EBC correlated with PTX3. Conclusion: Professional exposure to chlorinated agents increases EBC biomarkers of oxidative stress and inflammation.
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页码：115 / 122
页数：8
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