Emergence and compartmentalization of fatal multi-drug-resistant cytomegalovirus infection in a patient with autosomal-recessive severe combined immune deficiency

被引：20
作者：
Blackman, SC
Lurain, NS
Witte, DP
Filipovich, AH
Groen, P
Schleiss, MR
机构：
[1] Cincinnati Childrens Hosp, Ctr Med, Pediat Residency Training Program, Cincinnati, OH 45229 USA
[2] Cincinnati Childrens Hosp, Ctr Med, Div Infect Dis, Cincinnati, OH 45229 USA
[3] Cincinnati Childrens Hosp, Ctr Med, Div Pathol, Cincinnati, OH 45229 USA
[4] Cincinnati Childrens Hosp, Ctr Med, Div Hematol Oncol, Cincinnati, OH 45229 USA
[5] Rush Presbyterian St Lukes Med Ctr, Dept Immunol & Microbiol, Chicago, IL 60612 USA
来源：
JOURNAL OF PEDIATRIC HEMATOLOGY ONCOLOGY | 2004年 / 26卷 / 09期
关键词：
severe combined immunodeficiency; cytomegalovirus; antiviral therapy; antiviral resistance; UL97;
D O I：
10.1097/01.mph.0000135283.77668.6a
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
The authors describe a patient with autosomal-recessive severe combined immunodeficiency (SCID) with severe, multiorgan cytomegalovirus (CMV) disease. In the face of appropriate therapy, the patient developed a 100-fold gradient in viral load across the blood-brain barrier. Disseminated disease, including pneumonitis, contributed to a fatal outcome. Serial genotypic analyses revealed multiple UL97 and UL54 (DNA polymerase) mutations that conferred phenotypic resistance to all currently licensed systemic CMV antivirals.
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收藏
页码：601 / 605
页数：5
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