Stereoselective Synthesis of Novel Isonucleoside Analogues of Purine with a Tetrahydropyran Ring

被引：7

作者：

Estevez, Laura ^{[1
]}

Besada, Pedro ^{[1
]}

Fall, Yagamare ^{[1
]}

Teijeira, Marta ^{[1
]}

Teran, Carmen ^{[1
]}

机构：

[1] Univ Vigo, Dept Quim Organ, Fac Quim, Vigo 36310, Spain

来源：

SYNTHESIS-STUTTGART | 2010年 / 03期

关键词：

isonucleosides; heterocycles; tetrahydropyran; purine; Mitsunobu reaction; NATURAL OXETANOCIN; EXPANDED ANALOGS; NUCLEOSIDES; DESIGN;

D O I：

10.1055/s-0029-1217142

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

New tetrahydropyran isonucleoside derivatives of purine, with cis or trans configuration, were stereoselectively synthesized in moderate yield by a convergent strategy based on Mitsunobu coupling. The key starting material was a bicyclic lactone.

引用

页码：425 / 430

页数：6

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