The search for improved animal models of Alzheimer's disease and novel strategies for therapeutic intervention

被引:7
作者
Li, Chuanzhou [1 ,2 ,3 ]
Briner, Adam [1 ]
Gotz, Jurgen [1 ]
机构
[1] Univ Queensland, Clem Jones Ctr Ageing Dementia Res, Queensland Brain Inst, Brisbane, Qld 4072, Australia
[2] Huazhong Univ Sci & Technol, Dept Med Genet, Sch Basic Med, Wuhan 430030, Hubei, Peoples R China
[3] Huazhong Univ Sci & Technol, Tongji Med Coll, Wuhan 430030, Hubei, Peoples R China
关键词
Alzheimer's disease; blood-brain barrier; therapeutic ultrasound; MOUSE MODELS; AMYLOID-BETA; TAU;
D O I
10.4155/fmc-2019-0150
中图分类号
R914 [药物化学];
学科分类号
100701 ;
摘要
引用
收藏
页码:1853 / 1857
页数:5
相关论文
共 20 条
  • [1] Multimodal analysis of aged wild-type mice exposed to repeated scanning ultrasound treatments demonstrates long-term safety
    Blackmore, Daniel G.
    Turpin, Fabrice
    Mohamed, Abdalla Z.
    Zong, Fangrong
    Pandit, Rucha
    Pelekanos, Matthew
    Nasrallah, Fatima
    Sah, Pankaj
    Bartlett, Perry F.
    Gotz, Juergen
    [J]. THERANOSTICS, 2018, 8 (22): : 6233 - 6247
  • [2] ALZHEIMER DISEASE Rodent models for Alzheimer disease
    Goetz, Juergen
    Bodea, Liviu-Gabriel
    Goedert, Michel
    [J]. NATURE REVIEWS NEUROSCIENCE, 2018, 19 (10) : 583 - 598
  • [3] Default-mode network activity distinguishes Alzheimer's disease from healthy aging: Evidence from functional MRI
    Greicius, MD
    Srivastava, G
    Reiss, AL
    Menon, V
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2004, 101 (13) : 4637 - 4642
  • [4] Neuroinflammation in Alzheimer's disease
    Heneka, Michael T.
    Carson, Monica J.
    El Khoury, Joseph
    Landreth, Gary E.
    Brosseron, Frederic
    Feinstein, Douglas L.
    Jacobs, Andreas H.
    Wyss-Coray, Tony
    Vitorica, Javier
    Ransohoff, Richard M.
    Herrup, Karl
    Frautschy, Sally A.
    Finsen, Bente
    Brown, Guy C.
    Verkhratsky, Alexei
    Yamanaka, Koji
    Koistinaho, Jari
    Latz, Eicke
    Halle, Annett
    Petzold, Gabor C.
    Town, Terrence
    Morgan, Dave
    Shinohara, Mari L.
    Perry, V. Hugh
    Holmes, Clive
    Bazan, Nicolas G.
    Brooks, David J.
    Hunot, Stephane
    Joseph, Bertrand
    Deigendesch, Nikolaus
    Garaschuk, Olga
    Boddeke, Erik
    Dinarello, Charles A.
    Breitner, John C.
    Cole, Greg M.
    Golenbock, Douglas T.
    Kummer, Markus P.
    [J]. LANCET NEUROLOGY, 2015, 14 (04) : 388 - 405
  • [5] Hynynen K, 2003, ACT NEUR S, V86, P555
  • [6] NIA-AA Research Framework: Toward a biological definition of Alzheimer's disease
    Jack, Clifford R., Jr.
    Bennett, David A.
    Blennow, Kaj
    Carrillo, Maria C.
    Dunn, Billy
    Haeberlein, Samantha Budd
    Holtzman, David M.
    Jagust, William
    Jessen, Frank
    Karlawish, Jason
    Liu, Enchi
    Luis Molinuevo, Jose
    Montine, Thomas
    Phelps, Creighton
    Rankin, Katherine P.
    Rowe, Christopher C.
    Scheltens, Philip
    Siemers, Eric
    Snyder, Heather M.
    Sperling, Reisa
    Elliott, Cerise
    Masliah, Eliezer
    Ryan, Laurie
    Silverberg, Nina
    [J]. ALZHEIMERS & DEMENTIA, 2018, 14 (04) : 535 - 562
  • [7] Safety and Efficacy of Scanning Ultrasound Treatment of Aged APP23 Mice
    Leinenga, Gerhard
    Gotz, Jurgen
    [J]. FRONTIERS IN NEUROSCIENCE, 2018, 12
  • [8] Somatodendritic accumulation of Tau in Alzheimer's disease is promoted by Fyn-mediated local protein translation
    Li, Chuanzhou
    Gotz, Jurgen
    [J]. EMBO JOURNAL, 2017, 36 (21) : 3120 - 3138
  • [9] Blood-brain barrier opening in Alzheimer's disease using MR-guided focused ultrasound
    Lipsman, Nir
    Meng, Ying
    Bethune, Allison J.
    Huang, Yuexi
    Lam, Benjamin
    Masellis, Mario
    Herrmann, Nathan
    Heyn, Chinthaka
    Aubert, Isabelle
    Boutet, Alexandre
    Smith, Gwenn S.
    Hynynen, Kullervo
    Black, Sandra E.
    [J]. NATURE COMMUNICATIONS, 2018, 9
  • [10] Inflammation: the link between comorbidities, genetics, and Alzheimer's disease
    Newcombe, Estella A.
    Camats-Perna, Judith
    Silva, Mallone L.
    Valmas, Nicholas
    Huat, Tee Jong
    Medeiros, Rodrigo
    [J]. JOURNAL OF NEUROINFLAMMATION, 2018, 15