Associations between neighborhood built environment and cognition vary by apolipoprotein E genotype: Multi-Ethnic Study of Atherosclerosis

被引：28

作者：

Besser, Lilah ^{[1
]}

Galvin, James E. ^{[2
]}

Rodriguez, Daniel ^{[3
]}

Seeman, Teresa ^{[4
]}

Kukull, Walter ^{[5
]}

Rapp, Stephen R. ^{[6
,7
]}

Smith, Jennifer ^{[8
]}

机构：

[1] Florida Atlantic Univ, Inst Human Hlth & Dis Intervent, Sch Urban & Reg Planning, 777 Glades Rd,SO 284H, Boca Raton, FL 33431 USA

[2] Florida Atlantic Univ, Charles E Schmidt Coll Med, 777 Glades Rd,ME 104,First Floor, Boca Raton, FL 33431 USA

[3] Univ Calif Berkeley, Dept City & Reg Planning, Coll Environm Design, Off 313B,Wurster Hall 1820, Berkeley, CA 94720 USA

[4] Univ Calif Los Angeles, David Geffen Sch Med, 10945 Le Conte Ave,Suite 2339,PVUB Uberroth Bldg, Los Angeles, CA 90095 USA

[5] Univ Washington, Dept Epidemiol, Natl Alzheimers Coordinating Ctr, 4311 11th Ave NE,Suite 300, Seattle, WA 98105 USA

[6] Wake Forest Sch Med, Dept Psychiat & Behav Med, 791 Jonestown Rd, Winston Salem, NC 27103 USA

[7] Wake Forest Sch Med, Dept Publ Hlth Sci, 791 Jonestown Rd, Winston Salem, NC 27103 USA

[8] Univ Michigan, Dept Epidemiol, 1415 Washington Hts,Room 2631, Ann Arbor, MI 48109 USA

来源：

HEALTH & PLACE | 2019年 / 60卷

关键词：

Cognition; Neighborhood; Built environment; Older adults; Apolipoprotein E; Environment; SOCIOECONOMIC-STATUS; PHYSICAL-ACTIVITY; APOE GENOTYPE; OLDER-ADULTS; DEPRESSIVE SYMPTOMS; URBAN NEIGHBORHOOD; DECLINE; IMPAIRMENT; DEMENTIA; OUTCOMES;

D O I：

10.1016/j.healthplace.2019.102188

中图分类号：

R1 [预防医学、卫生学];

学科分类号：

1004 ; 120402 ;

摘要：

We examined whether neighborhood built environment (BE) and cognition associations in older adults vary by apolipoprotein E (APOE) genotype, a genetic risk factor for Alzheimer's disease (AD). We conducted a cross-sectional analysis of 4091 participants. Neighborhood characteristics included social and walking destination density (SDD, WDD), intersection density, and proportion of land dedicated to retail. Individuals were categorized as APOE epsilon 2 (lower AD risk), APOE epsilon 4 (higher AD risk), or APOE epsilon 3 carriers. Among APOE epsilon 2 carriers, greater proportion of land dedicated to retail was associated with better global cognition, and greater SDD, WDD, intersection density, and proportion of land dedicated to retail was associated with better processing speed. These associations were not observed in APOE epsilon 3 or epsilon 4 carriers. APOE epsilon 2 carriers may be more susceptible to the potentially beneficial effects of denser neighborhood BEs on cognition; however, longitudinal studies are needed.

引用

页数：9

共 65 条

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