Hormonal contraception and HIV acquisition: reanalysis using marginal structural modeling

被引：116

作者：

Morrison, Charles S. ^{[1
]}

Chen, Pai-Lien ^{[2
]}

Kwok, Cynthia ^{[2
]}

Richardson, Barbra A. ^{[3
,4
]}

Chipato, Tsungai ^{[5
]}

Mugerwa, Roy ^{[6
]}

Byamugisha, Josaphat ^{[7
]}

Padian, Nancy ^{[8
]}

Celentano, David D. ^{[9
]}

Salata, Robert A. ^{[10
]}

机构：

[1] Family Hlth Int, Behav & Biomed Res Div, Res Triangle Pk, NC 27709 USA

[2] Family Hlth Int, Div Biostat, Res Triangle Pk, NC 27709 USA

[3] Univ Washington, Dept Biostat, Seattle, WA 98195 USA

[4] Fred Hutchinson Canc Res Ctr, SCHARP, Seattle, WA 98104 USA

[5] Univ Zimbabwe, Dept Obstet & Gynaecol, Harare, Zimbabwe

[6] Makerere Univ, Fac Med, Kampala, Uganda

[7] Makerere Univ, Dept Obstet & Gynaecol, Kampala, Uganda

[8] Univ Calif Berkeley, Sch Publ Hlth, Dept Epidemiol, Berkeley, CA 94720 USA

[9] Johns Hopkins Univ, Bloomberg Sch Publ Hlth, Dept Epidemiol, Baltimore, MD USA

[10] Case Western Reserve Univ, Dept Med, Cleveland, OH 44106 USA

来源：

AIDS | 2010年 / 24卷 / 11期

基金：

美国国家卫生研究院;

关键词：

ANTIRETROVIRAL THERAPY; INFECTION; RISK; INFERENCE; SURVIVAL; COHORT; AGE;

D O I：

10.1097/QAD.0b013e32833a2537

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Hormonal contraceptives are used widely worldwide; their effect on HIV acquisition remains unresolved. We reanalyzed data from the Hormonal Contraception and HIV Study using marginal structural modeling to reduce selection bias due to time-dependent confounding. Replicating our original analysis closely, we found that depomedroxyprogesterone acetate (DMPA) but not combined oral contraceptive (COC) was associated with increased HIV acquisition. Also, young (1824 years) but not older women who used DMPA and COCs were at increased HIV risk.

引用

页码：1778 / 1781

页数：4

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