Metabolic Regulation of Macrophage Polarization in Cancer

被引：438

作者：

Mehla, Kamiya ^{[1
]}

Singh, Pankaj K. ^{[1
,2
,3
,4
]}

机构：

[1] Univ Nebraska Med Ctr, Eppley Inst Canc & Allied Dis, Omaha, NE 68198 USA

[2] Univ Nebraska Med Ctr, Dept Biochem & Mol Biol, Omaha, NE 68198 USA

[3] Univ Nebraska Med Ctr, Dept Pathol & Microbiol, Omaha, NE 68198 USA

[4] Univ Nebraska Med Ctr, Dept Genet Cell Biol & Anat, Omaha, NE 68198 USA

来源：

TRENDS IN CANCER | 2019年 / 5卷 / 12期

基金：

美国国家卫生研究院;

关键词：

TUMOR-ASSOCIATED MACROPHAGES; ADENOSINE A(2A) RECEPTOR; SUCCINATE-DEHYDROGENASE; ALTERNATIVE ACTIVATION; ITACONIC ACID; HIF-1-DEPENDENT REPRESSION; HUMAN MONOCYTES; CELL; ANGIOGENESIS; EXPRESSION;

D O I：

10.1016/j.trecan.2019.10.007

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Macrophages act as scavengers, modulating the immune response against pathogens and maintaining tissue homeostasis. Metabolism governs macrophage differentiation, polarization, mobilization, and the ability to mount an effective antitumor response. However, in cancer, the tumor microenvironment (TME) can actively reprogram macrophage metabolism either by direct exchange of metabolites or through cytokines and other signaling mediators. Thus, metabolic reprogramming holds potential for modulating macrophages and developing new therapeutic approaches. In this review, we provide an overview of macrophage metabolism as it relates to macrophage function and plasticity in cancer.

引用

页码：822 / 834

页数：13

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