Physiological functions and therapeutic applications of neutral sphingomyelinase and acid sphingomyelinase

被引：52
作者：
Xiang, Hongjiao [1 ]
Jin, Shengjie [1 ]
Tan, Fenglang [1 ]
Xu, Yifan [1 ]
Lu, Yifei [1 ]
Wu, Tao [1 ]
机构：
[1] Shanghai Univ Tradit Chinese Med, Inst Interdisciplinary Integrat Med Res, Shanghai, Peoples R China
来源：
BIOMEDICINE & PHARMACOTHERAPY | 2021年 / 139卷
基金：
中国国家自然科学基金;
关键词：
NSM; ASM; Ceramide; Apoptosis; Cancer; Atherosclerosis; CELL-DEATH; INDUCED APOPTOSIS; CIGARETTE-SMOKE; SECRETORY SPHINGOMYELINASE; INFLAMMATORY RESPONSE; DISEASE PATHOLOGY; ENDOTHELIAL-CELLS; SIGNALING PATHWAY; OXIDATIVE STRESS; OLIPUDASE ALPHA;
D O I：
10.1016/j.biopha.2021.111610
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
Sphingomyelin (SM) can be converted into ceramide (Cer) by neutral sphingomyelinase (NSM) and acid sphingomyelinase (ASM). Cer is a second messenger of lipids and can regulate cell growth and apoptosis. Increasing evidence shows that NSM and ASM play key roles in many processes, such as apoptosis, immune function and inflammation. Therefore, NSM and ASM have broad prospects in clinical treatments, especially in cancer, cardiovascular diseases (such as atherosclerosis), nervous system diseases (such as Alzheimer's disease), respiratory diseases (such as chronic obstructive pulmonary disease) and the phenotype of dwarfisms in adolescents, playing a complex regulatory role. This review focuses on the physiological functions of NSM and ASM and summarizes their roles in certain diseases and their potential applications in therapy.
引用
收藏
页数：13
相关论文
共 174 条
[1]   Ceramide:: does it matter for T cells? [J].
Adam, D ;
Heinrich, M ;
Kabelitz, D ;
Schütze, S .
TRENDS IN IMMUNOLOGY, 2002, 23 (01) :1-4
[2]   Neutral sphingomyelinase inhibition participates to the benefits of N-acetylcysteine treatment in post-myocardial infarction failing heart rats [J].
Adamy, Christophe ;
Mulder, Paul ;
Khouzami, Lara ;
Andrieu-Abadie, Nathalie ;
Defer, Nicole ;
Candiani, Gabriele ;
Pavoine, Catherine ;
Caramelle, Philippe ;
Souktani, Richard ;
Le Corvoisier, Philippe ;
Perier, Magali ;
Kirsch, Matthias ;
Damy, Thibaud ;
Berdeaux, Alain ;
Levade, Thierry ;
Thuillez, Christian ;
Hittinger, Luc ;
Pecker, Francoise .
JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY, 2007, 43 (03) :344-353
[3]   Structure of human nSMase2 reveals an interdomain allosteric activation mechanism for ceramide generation [J].
Airola, Michael V. ;
Shanbhogue, Prajna ;
Shamseddine, Achraf A. ;
Guja, Kip E. ;
Senkal, Can E. ;
Maini, Rohan ;
Bartke, Nana ;
Wu, Bill X. ;
Obeid, Lina M. ;
Garcia-Diaz, Miguel ;
Hannun, Yusuf A. .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2017, 114 (28) :E5549-E5558
[4]   Connection of lipid peroxide oxidation with the sphingomyelin pathway in the development of Alzheimer's disease [J].
Alessenko, AV ;
Bugrova, AE ;
Dudnik, LB .
BIOCHEMICAL SOCIETY TRANSACTIONS, 2004, 32 :144-146
[5]   L-carnitine prevents doxorubicin-induced apoptosis of cardiac myocytes:: role of inhibition of ceramide generation [J].
Andrieu-Abadie, N ;
Jaffrézou, JP ;
Hatem, S ;
Laurent, G ;
Levade, T ;
Mercadier, JJ .
FASEB JOURNAL, 1999, 13 (12) :1501-1510
[6]   RCeveierwamide and ceramide 1-phosphate in health and disease [J].
Arana, Lide ;
Gangoiti, Patricia ;
Ouro, Alberto ;
Trueba, Miguel ;
Gomez-Munoz, Antonio .
LIPIDS IN HEALTH AND DISEASE, 2010, 9
[7]   Oxidative stress and potential applications of free radical scavengers in glaucoma [J].
Aslan, Mutay ;
Dogan, Serdar ;
Kucuksayan, Ertan .
REDOX REPORT, 2013, 18 (02) :76-87
[8]   The sphingomyelin-ceramide signaling pathway is involved in oxidized low density lipoprotein-induced cell proliferation [J].
Auge, N ;
Andrieu, N ;
NegreSalvayre, A ;
Thiers, JC ;
Levade, T ;
Salvayre, R .
JOURNAL OF BIOLOGICAL CHEMISTRY, 1996, 271 (32) :19251-19255
[9]   Fluorescent annexin A1 reveals dynamics of ceramide platforms in living cells [J].
Babiychuk, Eduard B. ;
Monastyrskaya, Katia ;
Draeger, Annette .
TRAFFIC, 2008, 9 (10) :1757-1775
[10]   Microglial p38α MAPK is a key regulator of proinflammatory cytokine up-regulation induced by toll-like receptor (TLR) ligands or beta-amyloid (Aβ) [J].
Bachstetter, Adam D. ;
Xing, Bin ;
de Almeida, Lucia ;
Dimayuga, Edgardo R. ;
Watterson, D. Martin ;
Van Eldik, Linda J. .
JOURNAL OF NEUROINFLAMMATION, 2011, 8
12345678910