Differential expression of Hyaluronic Acid Binding protein 1 (HABP1)/P32/C1QBP during progression of epidermal carcinoma

被引:36
作者
Ghosh, I
Chowdhury, AR
Rajeswari, MR
Datta, K [1 ]
机构
[1] Jawaharlal Nehru Univ, Sch Environm Sci, Biochem Lab, New Delhi 110067, India
[2] All India Inst Med Sci, Dept Biochem, New Delhi 110029, India
关键词
hyaluronan; hyaluronan binding protein 1; p32; gC1qR carcinoma;
D O I
10.1023/B:MCBI.0000049362.04033.ea
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
Our laboratory has characterized a novel cell surface glycoprotein, Hyaluronic Acid Binding Protein 1 (HABP1), interacting specifically with hyaluronan (HA) and regulating HA-mediated cellular event. The involvement of HA in different stages of carcinoma is well documented. In the present communication, the expression profile of HABP1 was investigated from initiation to progression of epidermal carcinoma in mice, induced by benzo[a] pyrene (B[a]P) exposure. During tumor initiation, HABP1 accumulated in inflammatory subsquamous tissue and with progression, the protein, was also seen to overexpress in papillomatic and acanthotic tissue. With the onset of metastasis, HABP1 overexpression was confined to metastatic islands, while it disappeared gradually from the surrounding mass. Such expression profiles in metastasized tissue were supported by decreased levels of HABP1, both at protein and transcript levels. These observations taken together suggest that the changes in HABP1 level coincide with specific stages of tumor progression, that lead to disruption of its interaction with HA, implying a role in the regulation of tumor metastasis.
引用
收藏
页码:133 / 139
页数:7
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