CHITOSAN MICROPARTICLES LOADED WITH ANTIDIABETIC DRUGS - PREPARATION AND CHARACTERIZATION

被引：0

作者：

Avram, Iustina ^{[1
]}

Lupascu, Florentina Gianina ^{[1
]}

Confederat, Luminita ^{[1
]}

Constantin, Sandra Madalina ^{[1
]}

Stan, Cristinel Ionel ^{[2
]}

Profire, Lenuta ^{[1
]}

机构：

[1] Grigore T Popa Univ Med & Pharm, Dept Pharmaceut Chem, Fac Pharm, 16 Univ St, Iasi 700115, Romania

[2] Grigore T Popa Univ Med & Pharm, Dept Morphofunct Sci, Fac Med, 16 Univ St, Iasi 700115, Romania

来源：

FARMACIA | 2017年 / 65卷 / 03期

关键词：

chitosan; metformin; glibenclamide; microparticles; polymer matrices; TYPE-2; DIABETES-MELLITUS; GLIBENCLAMIDE; OLD; SULFONYLUREAS; METFORMIN; THERAPY;

D O I：

暂无

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The objective of this study was to develop new binary polymeric systems based on chitosan in order to achieve an improvement of the pharmacokinetic and pharmacological profile of the two most used oral antidiabetic drugs - metformin and glibenclamide. The presence of the antidiabetic drugs in the polymer matrix was proved using IR spectroscopy. The optimized formulations were studied in terms of morphology, particle size, swelling degree and loading efficiency. The binary polymeric formulations (chitosan-metformin-glibenclamide) were characterized by the swelling degree and loading efficiency, higher than the unitary polymeric systems (chitosan-metformin and chitosan-glibenclamide). The highest loading efficiency was shown by the chitosan-metformin-glibenclamide formulation in 1:0.5:0.5 ratio (w/w/w).

引用

页码：443 / 448

页数：6

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