Direct Asymmetric Reductive Amination for the Synthesis of Chiral -Arylamines

被引：75

作者：

Huang, Haizhou ^{[1
]}

Liu, Xiaoyan ^{[1
]}

Zhou, Le ^{[1
]}

Chang, Mingxin ^{[1
]}

Zhang, Xumu ^{[2
]}

机构：

[1] Northwest A&F Univ, Dept Chem & Chem Engn, 22 Xinong Rd, Yangling 712100, Shaanxi, Peoples R China

[2] Rutgers State Univ, Dept Chem & Chem Biol, Piscataway, NJ 08854 USA

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2016年 / 55卷 / 17期

基金：

中国国家自然科学基金;

关键词：

asymmetric catalysis; enantioselectivity; iridium; ligand design; reductions; BRONSTED ACID; ENANTIOSELECTIVE SYNTHESIS; COOPERATIVE CATALYSIS; HYDROGENATION; KETONES; LIGANDS; INHIBITOR; PROTEASE; AMINES;

D O I：

10.1002/anie.201601025

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The highly efficient and direct asymmetric reductive amination of arylacetones catalyzed by an iridium complex for the preparation of enantiomerically pure -arylamines is described. The monodentate phosphoramidite ligand exhibits superb reactivity (TONs of up to 20000) and enantioselectivity (up to 99% ee). Additives played important roles in this reductive coupling reaction.

引用

页码：5309 / 5312

页数：4

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