Near infrared-fluorescent and magnetic resonance imaging molecular probe with high T1 relaxivity for in vivo multimodal imaging

被引：34

作者：

Guo, Kevin ^{[1
]}

Berezin, Mikhail Y. ^{[1
]}

Zheng, Jie ^{[1
]}

Akers, Walter ^{[1
]}

Lin, Franck ^{[2
]}

Teng, Bao ^{[3
]}

Vasalatiy, Olga ^{[3
]}

Gandjbakhche, Amir ^{[4
]}

Griffiths, Gary L. ^{[3
]}

Achilefu, Samuel ^{[1
,2
,5
]}

机构：

[1] Washington Univ, Dept Radiol, St Louis, MO 63110 USA

[2] Washington Univ, Dept Biomed Engn, St Louis, MO 63110 USA

[3] NHLBI, Imaging Probe Dev Ctr, NIH, Bethesda, MD 20892 USA

[4] Eunice Shriver NICHD, NIH, Bethesda, MD 20892 USA

[5] Washington Univ, Dept Biochem & Mol Biophys, St Louis, MO 63110 USA

来源：

CHEMICAL COMMUNICATIONS | 2010年 / 46卷 / 21期

基金：

美国国家卫生研究院;

关键词：

MRI CONTRAST AGENTS; HUMAN SERUM-ALBUMIN; GD-DTPA; RELAXATION; NANOPARTICLE; LIFETIME; DESIGN; MS-325;

D O I：

10.1039/c000536c

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A new gadolinium chelating NIR fluorescent molecular probe increases T-1 relaxivity of water protons, facilitating combined optical and magnetic resonance imaging.

引用

页码：3705 / 3707

页数：3

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