Near infrared-fluorescent and magnetic resonance imaging molecular probe with high T1 relaxivity for in vivo multimodal imaging

被引：34

作者：

Guo, Kevin ^{[1
]}

Berezin, Mikhail Y. ^{[1
]}

Zheng, Jie ^{[1
]}

Akers, Walter ^{[1
]}

Lin, Franck ^{[2
]}

Teng, Bao ^{[3
]}

Vasalatiy, Olga ^{[3
]}

Gandjbakhche, Amir ^{[4
]}

Griffiths, Gary L. ^{[3
]}

Achilefu, Samuel ^{[1
,2
,5
]}

机构：

[1] Washington Univ, Dept Radiol, St Louis, MO 63110 USA

[2] Washington Univ, Dept Biomed Engn, St Louis, MO 63110 USA

[3] NHLBI, Imaging Probe Dev Ctr, NIH, Bethesda, MD 20892 USA

[4] Eunice Shriver NICHD, NIH, Bethesda, MD 20892 USA

[5] Washington Univ, Dept Biochem & Mol Biophys, St Louis, MO 63110 USA

来源：

CHEMICAL COMMUNICATIONS | 2010年 / 46卷 / 21期

基金：

美国国家卫生研究院;

关键词：

MRI CONTRAST AGENTS; HUMAN SERUM-ALBUMIN; GD-DTPA; RELAXATION; NANOPARTICLE; LIFETIME; DESIGN; MS-325;

D O I：

10.1039/c000536c

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A new gadolinium chelating NIR fluorescent molecular probe increases T-1 relaxivity of water protons, facilitating combined optical and magnetic resonance imaging.

引用

页码：3705 / 3707

页数：3

共 27 条

[1] Lighting up tumors with receptor-specific optical molecular probes [J].

Achilefu, S .

TECHNOLOGY IN CANCER RESEARCH & TREATMENT, 2004, 3 (04) :393-409

[2] An investigation of the toxicity of gadolinium based MRI contrast agents using neutron activation analysis [J].

Bartolini, ME ;

Pekar, J ;

Chettle, DR ;

McNeill, F ;

Scott, A ;

Sykes, J ;

Prato, FS ;

Moran, GR .

MAGNETIC RESONANCE IMAGING, 2003, 21 (05) :541-544

[3] Ratiometric analysis of fluorescence lifetime for probing binding sites in albumin with near-infrared fluorescent molecular probes [J].

Berezin, Mikhail Y. ;

Lee, Hyeran ;

Akers, Walter ;

Nikiforovich, Gregory ;

Achilefu, Samuel .

PHOTOCHEMISTRY AND PHOTOBIOLOGY, 2007, 83 (06) :1371-1378

[4] Near infrared dyes as lifetime solvatochromic probes for micropolarity measurements of biological systems [J].

Berezin, Mikhail Y. ;

Lee, Hyeran ;

Akers, Walter ;

Achilefu, Samuel .

BIOPHYSICAL JOURNAL, 2007, 93 (08) :2892-2899

[5] Radioactivity-Synchronized Fluorescence Enhancement Using a Radionuclide Fluorescence-Quenched Dye [J].

Berezin, Mikhail Y. ;

Guo, Kevin ;

Teng, Bao ;

Edwards, W. Barry ;

Anderson, Carolyn J. ;

Vasalatiy, Olga ;

Gandjbakhche, Amir ;

Griffiths, Gary L. ;

Achilefu, Samuel .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2009, 131 (26) :9198-+

[6] Gadolinium(III) chelates as MRI contrast agents: Structure, dynamics, and applications [J].

Caravan, P ;

Ellison, JJ ;

McMurry, TJ ;

Lauffer, RB .

CHEMICAL REVIEWS, 1999, 99 (09) :2293-2352

[7] The interaction of MS-325 with human serum albumin and its effect on proton relaxation rates [J].

Caravan, P ;

Cloutier, NJ ;

Greenfield, MT ;

McDermid, SA ;

Dunham, SU ;

Bulte, JWM ;

Amedio, JC ;

Looby, RJ ;

Supkowski, RM ;

Horrocks, WD ;

McMurry, TJ ;

Lauffer, RB .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2002, 124 (12) :3152-3162

[8] When are two waters worse than one? Doubling the hydration number of a Gd-DTPA derivative decreases relaxivity [J].

Caravan, P ;

Amedio, JC ;

Dunham, SU ;

Greenfield, MT ;

Cloutier, NJ ;

McDermid, SA ;

Spiller, M ;

Zech, SG ;

Looby, RJ ;

Raitsimring, AM ;

McMurry, TJ ;

Lauffer, RB .

CHEMISTRY-A EUROPEAN JOURNAL, 2005, 11 (20) :5866-5874

[9] Strategies for increasing the sensitivity of gadolinium based MRI contrast agents [J].

Caravan, Peter .

CHEMICAL SOCIETY REVIEWS, 2006, 35 (06) :512-523

[10] Protein-Targeted Gadolinium-Based Magnetic Resonance Imaging (MRI) Contrast Agents: Design and Mechanism of Action [J].

Caravan, Peter .

ACCOUNTS OF CHEMICAL RESEARCH, 2009, 42 (07) :851-862

← 1 2 3 →