Discovery of the first antibacterial small molecule inhibitors of MurB

被引：81
作者：
Bronson, JJ [1 ]
DenBleyker, KL [1 ]
Falk, PJ [1 ]
Mate, RA [1 ]
Ho, HT [1 ]
Pucci, MJ [1 ]
Snyder, LB [1 ]
机构：
[1] Bristol Myers Squibb Co, Pharmaceut Res Inst, Wallingford, CT 06492 USA
来源：
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2003年 / 13卷 / 05期
关键词：
D O I：
10.1016/S0960-894X(02)01076-4
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
A series of imidazolinone analogues was synthesized and shown to possess potent MurB inhibitory as well as good antibacterial activity. (C) 2003 Elsevier Science Ltd. All rights reserved.
引用
收藏
页码：873 / 875
页数：3
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