Secondary palatal closure in rats in association with relative maternofetal levels of folic acid, vitamin B12, and homocysteine

被引：11
作者：
Weingaertner, Jens
Maile, Sergei
Proff, Peter
Reicheneder, Claudia
Bienengraeber, Volker
Fanghaenel, Jochen
Gedrange, Tomas
机构：
[1] Ernst Moritz Arndt Univ Greifswald, Inst Anat & Cellbiol, D-17475 Greifswald, Germany
[2] Ernst Moritz Arndt Univ Greifswald, Dept Orthodont Prevent & Pediat Dent, D-17475 Greifswald, Germany
[3] Univ Rostock, Dept Oromaxillofacial Surg, D-18057 Rostock, Germany
来源：
ANNALS OF ANATOMY-ANATOMISCHER ANZEIGER | 2007年 / 189卷 / 03期
关键词：
folic acid; vitamin B12; homocysteine; secondary palatal closure; CLEFT-LIP; FUNCTIONAL-ANATOMY; FACIAL EXPRESSION; MUSCLES;
D O I：
10.1016/j.aanat.2006.10.006
中图分类号：
R602 [外科病理学、解剖学]; R32 [人体形态学];
学科分类号：
100101 ;
摘要：
Animal experiments are used in embryological and teratological studies of matters relevant to humans. In gravid rats, a decrease in the levels of folic acid and vitamin B12 was observed in maternal blood and in amniotic fluid. At the time of secondary palatal closure (14th day of pregnancy), the folic acid level of the amniotic fluid was 73% tower than that of the maternal blood. A drop in vitamin B12 in conjunction with an increase in amniotic homocysteine levels is seen as a risk factor for malformation of the palate. The understanding of causes of cleft generation could lead to a prophylactic treatment approach. (c) 2007 Elsevier GmbH. All rights reserved.
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页码：229 / 233
页数：5
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