Emergence of mcr-1 and mcr-3 variants coding for plasmid-mediated colistin resistance in Escherichia coli isolates from food- producing animals in South Korea

被引：23

作者：

Belaynehe, Kuastros Mekonnen ^{[1
]}

Shin, Seung Won ^{[1
]}

Park, Kyung Yoon ^{[2
]}

Jang, Ji Young ^{[2
]}

Won, Ho Geun ^{[1
,3
]}

Yoon, In Joong ^{[3
]}

Yoo, Han Sang ^{[1
,4
]}

机构：

[1] Seoul Natl Univ, Coll Vet Med, Dept Infect Dis, Seoul 08826, South Korea

[2] Green Cross Vet Prod, Res Unit, Yongin 17066, South Korea

[3] Chung Ang Vaccine Lab, Daejeon 34055, South Korea

[4] Seoul Natl Univ, Inst Green Bio Sci & Technol, Pyeongchang 25340, South Korea

来源：

INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES | 2018年 / 72卷

关键词：

mcr-3; gene; mcr-1; Colistin resistance; Healthy animals; Transferability; GENE;

D O I：

10.1016/j.ijid.2018.05.011

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

We hereby report the first characterization of mcr-3 gene from healthy animals in South Korea. Out of 636 E. coli isolates, collected between 2014- 2017, nine colistin resistant isolates were screened for the presence of mcr-1 and mcr-3 genes. Nine (1.4%) isolates had shown resistance for colistin and among them three and two isolates were mcr-1 harboring and mcr-3 harboring strains, respectively. All the colistin-resistant isolates were multidrug-resistant, mcr-1 and mcr-3 genes were confirmed to be transferred to a recipient E. coli J53 AZ(R). (C) 2018 The Authors. Published by Elsevier Ltd on behalf of International Society for Infectious Diseases. This is an open access article under the CC BY-NC-ND license.

引用

页码：22 / 24

页数：3

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